PMID- 19389147
OWN - NLM
STAT- MEDLINE
DCOM- 20090828
LR  - 20211020
IS  - 1528-1167 (Electronic)
IS  - 0013-9580 (Print)
IS  - 0013-9580 (Linking)
VI  - 50
IP  - 8
DP  - 2009 Aug
TI  - Mortality in captive baboons with seizures: a new model for SUDEP?
PG  - 1995-8
LID - 10.1111/j.1528-1167.2009.02073.x [doi]
AB  - Because the baboon is a model of primary generalized epilepsy, we were interested 
      in mortality of captive animals with a history of witnessed seizures. Causes of 
      natural death were investigated in 46 seizure baboons (SZ) and 78 nonepileptic 
      controls (CTL), all of which underwent a complete pathologic examination at the 
      Southwest Foundation for Biomedical Research (SFBR) in San Antonio. SZ animals 
      died at a younger age than the control baboons (p < 0.001). Almost all epileptic 
      baboons that died suddenly without an apparent cause (SZ-UKN), had pulmonary 
      congestion or edema without evidence of trauma, systemic illness, or heart 
      disease, compared to nine controls (12%) (p < 0.001), most of which demonstrated 
      evidence of a concurrent illness. Serosanguineous bronchial secretions were found 
      in 15 SZ-UKN baboons (58%), but in only three controls (4%) (p < 0.001). Chronic 
      multifocal fibrotic changes in myocardium were noted in only three (12%) of 
      SZ-UKN baboons and one control baboon. Based upon these results, untreated 
      seizures appear to reduce the life expectancy of captive baboons. Sudden 
      unexpected death in epilepsy (SUDEP) may be a common cause of natural death in 
      epileptic baboons.
FAU - Szabo, C Akos
AU  - Szabo CA
AD  - South Texas Comprehensive Epilepsy Center, Department of Neurology, University of 
      Texas Health Science Center at San Antonio, San Antonio, Texas 78229-7883, USA. 
      szabo@uthscsa.edu
FAU - Knape, Koyle D
AU  - Knape KD
FAU - Leland, M Michelle
AU  - Leland MM
FAU - Feldman, Jake
AU  - Feldman J
FAU - McCoy, Karin J M
AU  - McCoy KJ
FAU - Hubbard, Gene B
AU  - Hubbard GB
FAU - Williams, Jeff T
AU  - Williams JT
LA  - eng
GR  - R01 NS047755/NS/NINDS NIH HHS/United States
GR  - 1 R01 NS047755-01/NS/NINDS NIH HHS/United States
GR  - R21 NS065431/NS/NINDS NIH HHS/United States
GR  - R21 NS065431-01A1/NS/NINDS NIH HHS/United States
GR  - P51 OD011133/OD/NIH HHS/United States
GR  - C06 RR014578/RR/NCRR NIH HHS/United States
GR  - C06 RR15456/RR/NCRR NIH HHS/United States
GR  - C06 RR015456/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20090406
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
SB  - IM
MH  - Animals
MH  - Case-Control Studies
MH  - Cause of Death
MH  - *Death, Sudden
MH  - Disease Models, Animal
MH  - Electroencephalography
MH  - Epilepsy/mortality/pathology/*veterinary
MH  - Female
MH  - Male
MH  - Monkey Diseases/*mortality
MH  - Papio/*physiology
MH  - Retrospective Studies
MH  - Risk Factors
PMC - PMC2935173
MID - NIHMS201429
EDAT- 2009/04/25 09:00
MHDA- 2009/08/29 09:00
PMCR- 2010/09/07
CRDT- 2009/04/25 09:00
PHST- 2009/04/25 09:00 [entrez]
PHST- 2009/04/25 09:00 [pubmed]
PHST- 2009/08/29 09:00 [medline]
PHST- 2010/09/07 00:00 [pmc-release]
AID - EPI2073 [pii]
AID - 10.1111/j.1528-1167.2009.02073.x [doi]
PST - ppublish
SO  - Epilepsia. 2009 Aug;50(8):1995-8. doi: 10.1111/j.1528-1167.2009.02073.x. Epub 
      2009 Apr 6.