PMID- 19389428
OWN - NLM
STAT- MEDLINE
DCOM- 20090831
LR  - 20121115
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 203
IP  - 1
DP  - 2009 Oct 12
TI  - Habituation-induced neural plasticity in the hippocampus and prefrontal cortex 
      mediated by MMP-3.
PG  - 27-34
LID - 10.1016/j.bbr.2009.04.014 [doi]
AB  - Head-shake response (HSR) habituation was presently used to investigate the 
      phenomena of spontaneous recovery and neural plasticity. Independent groups of 
      rats were presented with five consecutive habituation sessions separated by 
      inter-session intervals (ISIs) of 2, 24 or 72 h. At the conclusion of testing 
      hippocampus and prefrontal cortex tissue samples were collected for determination 
      of matrix metalloproteinase-3 (MMP-3:stromelysin-1) expression as a marker of 
      neural plasticity. The results indicated that by the fifth session the 2 h ISI 
      group showed no spontaneous recovery, the 72 h ISI group revealed nearly complete 
      spontaneous recovery; while the 24 h ISI group showed intermediate recovery. 
      MMP-3 expression in the hippocampus and prefrontal cortex was elevated in the 2 
      and 72 h ISI groups, but not in the 24 h group. A second experiment utilized 
      7-day osmotic pumps to intracerebroventricularly infuse an MMP-3 inhibitor for 6 
      days. The animals were then tested on the seventh day using the 2 h ISI protocol. 
      Delivery of the MMP-3 inhibitor facilitated spontaneous recovery, thus 
      compromising the animal's ability to appropriately habituate. This effect was 
      accompanied by a significant inhibition of hippocampus and prefrontal cortex 
      MMP-3 expression. These results suggest that elevations in hippocampus and 
      prefrontal cortex MMP-3 expression contribute to this simplest form of learning 
      and may be a mechanism underlying spontaneous recovery.
FAU - Wright, John W
AU  - Wright JW
AD  - Department of Psychology, Washington State University, Pullman, WA 99164-4820, 
      United States. wrightjw@wsu.edu
FAU - Meighan, Peter C
AU  - Meighan PC
FAU - Brown, Travis E
AU  - Brown TE
FAU - Wiediger, Roberta V
AU  - Wiediger RV
FAU - Sorg, Barbara A
AU  - Sorg BA
FAU - Harding, Joseph W
AU  - Harding JW
LA  - eng
GR  - DA023729/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090421
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Matrix Metalloproteinase Inhibitors)
RN  - EC 3.4.24.- (Matrix Metalloproteinases, Secreted)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Blotting, Western
MH  - Enzyme Inhibitors/pharmacology
MH  - Habituation, Psychophysiologic/drug effects/*physiology
MH  - Head
MH  - Hippocampus/drug effects/*physiology
MH  - Learning/drug effects/physiology
MH  - Male
MH  - Matrix Metalloproteinase 3/*metabolism
MH  - Matrix Metalloproteinase Inhibitors
MH  - Matrix Metalloproteinases, Secreted/antagonists & inhibitors
MH  - Neuronal Plasticity/drug effects/*physiology
MH  - Prefrontal Cortex/drug effects/*physiology
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Time Factors
EDAT- 2009/04/25 09:00
MHDA- 2009/09/01 06:00
CRDT- 2009/04/25 09:00
PHST- 2008/05/06 00:00 [received]
PHST- 2009/04/09 00:00 [revised]
PHST- 2009/04/13 00:00 [accepted]
PHST- 2009/04/25 09:00 [entrez]
PHST- 2009/04/25 09:00 [pubmed]
PHST- 2009/09/01 06:00 [medline]
AID - S0166-4328(09)00245-9 [pii]
AID - 10.1016/j.bbr.2009.04.014 [doi]
PST - ppublish
SO  - Behav Brain Res. 2009 Oct 12;203(1):27-34. doi: 10.1016/j.bbr.2009.04.014. Epub 
      2009 Apr 21.