PMID- 19391110
OWN - NLM
STAT- MEDLINE
DCOM- 20091203
LR  - 20121115
IS  - 1099-1263 (Electronic)
IS  - 0260-437X (Linking)
VI  - 29
IP  - 6
DP  - 2009 Aug
TI  - Differential developmental toxicities of di-n-hexyl phthalate and dicyclohexyl 
      phthalate administered orally to rats.
PG  - 510-21
LID - 10.1002/jat.1436 [doi]
AB  - The objective of this study was to evaluate the developmental toxic potential of 
      di-n-hexyl phthalate (DnHP) and dicyclohexyl phthalate (DCHP) in rats. Pregnant 
      Sprague-Dawley rats were exposed to DnHP or DCHP at doses of 0 (olive oil), 250, 
      500 and 750 mg kg(-1) per day, by gavage, on gestational days (GD) 6-20. Maternal 
      food consumption and body weight gain were significantly reduced at 750 mg kg(-1) 
      per day of DnHP and at the two high doses of DCHP. Slight changes in liver weight 
      associated with peroxisomal enzyme induction were seen in dams treated with DnHP 
      or DCHP. DnHP caused dose-related developmental toxic effects, including marked 
      embryo mortality at 750 mg kg(-1) per day, and presence of malformations (mainly 
      cleft palate, eye defects and axial skeleton abnormalities) and significant 
      decreases in fetal weight at 500 and 750 mg kg(-1) per day. Significant delay of 
      ossification and increase in the incidence of skeletal variants (e.g. 
      supernumerary lumbar ribs) also appeared at 250 mg kg(-1) per day. DCHP produced 
      fetal growth retardation at 750 mg kg(-1) per day, as evidenced by significant 
      reduction of fetal weight. DnHP and DCHP induced a significant and dose-related 
      decrease in the anogenital distance of male fetuses at all doses, and there was a 
      significant increase in the incidence of male fetuses with undescended testis at 
      500 and 750 mg kg(-1) per day of DnHP. In conclusion, DnHP showed clear 
      embryolethality and teratogenicity, but not DCHP. There was evidence that both 
      phthalates could alter the development of the male reproductive system after in 
      utero exposure, DnHP being much more potent than DCHP.
CI  - Copyright 2009 John Wiley & Sons, Ltd.
FAU - Saillenfait, Anne-Marie
AU  - Saillenfait AM
AD  - Institut National de Recherche et de Securite, Rue du Morvan, CS, 60027, 54519 
      Vandoeuvre Cedex, France. anne-marie.saillenfait@inrs.fr
FAU - Gallissot, Frederic
AU  - Gallissot F
FAU - Sabate, Jean-Philippe
AU  - Sabate JP
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Appl Toxicol
JT  - Journal of applied toxicology : JAT
JID - 8109495
RN  - 0 (Phthalic Acids)
RN  - 0 (Plasticizers)
RN  - 42MAH1QFG5 (di-n-hexyl phthalate)
RN  - CGD15M7H2N (dicyclohexyl phthalate)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Congenital Abnormalities/*etiology
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Fetal Development/*drug effects
MH  - Fetal Resorption/*chemically induced
MH  - Gestational Age
MH  - Isomerism
MH  - Male
MH  - Phthalic Acids/*toxicity
MH  - Plasticizers/chemistry/*toxicity
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Toxicity Tests, Chronic
EDAT- 2009/04/25 09:00
MHDA- 2009/12/16 06:00
CRDT- 2009/04/25 09:00
PHST- 2009/04/25 09:00 [entrez]
PHST- 2009/04/25 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
AID - 10.1002/jat.1436 [doi]
PST - ppublish
SO  - J Appl Toxicol. 2009 Aug;29(6):510-21. doi: 10.1002/jat.1436.