PMID- 19392575
OWN - NLM
STAT- MEDLINE
DCOM- 20100126
LR  - 20220309
IS  - 1744-7682 (Electronic)
IS  - 1471-2598 (Linking)
VI  - 9
IP  - 5
DP  - 2009 May
TI  - Dendritic cells: therapy and imaging.
PG  - 539-64
LID - 10.1517/14712590902867739 [doi]
AB  - BACKGROUND: Dendritic cells (DCs) play a major role in cell-mediated 
      immunotherapy. In this approach, DCs are isolated from cancer patients and pulsed 
      with exogenous and specific tumor antigens in vitro, and the antigen-loaded DCs 
      are then transferred to the hosts to enhance the immune response against tumor 
      targets. Clinical observations and animal studies have shown that tumors can 
      elicit immune responses caused by tumor infiltration of T-lymphocytes. Several 
      pilot clinical trials have been recently conducted using this strategy for 
      treating several types of cancers. OBJECTIVE: To optimize DC-based therapy with 
      emerging molecular imaging techniques. METHODS: A review of the most current 
      literature on DCs and imaging work. RESULTS/CONCLUSION: The translational 
      application of DC-based therapy can be supported greatly through molecular 
      imaging. New discoveries on DC migration and behavior in vivo will lead to new 
      advances in the treatment of a broad range of cancers.
FAU - Pham, Wellington
AU  - Pham W
AD  - Vanderbilt University, Institute of Imaging Science, Nashville, TN 37232-2310, 
      USA. wellington.pham@vanderbilt.edu
FAU - Kobukai, Saho
AU  - Kobukai S
FAU - Hotta, Chie
AU  - Hotta C
FAU - Gore, John C
AU  - Gore JC
LA  - eng
GR  - AG026366/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - England
TA  - Expert Opin Biol Ther
JT  - Expert opinion on biological therapy
JID - 101125414
SB  - IM
MH  - Animals
MH  - Clinical Trials as Topic/methods/trends
MH  - Dendritic Cells/*immunology/*transplantation
MH  - Diagnostic Imaging/*methods/trends
MH  - Humans
MH  - Microscopy, Fluorescence/methods/trends
MH  - Neoplasms/immunology/pathology/surgery
MH  - Tomography, Emission-Computed, Single-Photon/methods/trends
RF  - 234
EDAT- 2009/04/28 09:00
MHDA- 2010/01/27 06:00
CRDT- 2009/04/28 09:00
PHST- 2009/04/28 09:00 [entrez]
PHST- 2009/04/28 09:00 [pubmed]
PHST- 2010/01/27 06:00 [medline]
AID - 10.1517/14712590902867739 [doi]
PST - ppublish
SO  - Expert Opin Biol Ther. 2009 May;9(5):539-64. doi: 10.1517/14712590902867739.