PMID- 19392789
OWN - NLM
STAT- MEDLINE
DCOM- 20090821
LR  - 20221207
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 74
IP  - 1
DP  - 2009 Jul
TI  - TNF block haplotypes associated with conserved MHC haplotypes in European, Asian 
      and Australian Aboriginal donors.
PG  - 57-61
LID - 10.1111/j.1399-0039.2009.01258.x [doi]
AB  - Associations between major histocompatibility complex (MHC) ancestral haplotypes 
      (AHs) and immunopathological diseases are traditionally ascribed to human 
      leukocyte antigen (HLA) class I or class II alleles. However, polymorphisms in 
      TNF and nearby genes in the central MHC can influence risk. We have defined TNF 
      block haplotypes in Asian, European and Australian Aboriginal donors and shown 
      conservation of TNF block haplotypes in geographically distinct populations, 
      consistent with a common evolutionary origin. Here we show that most TNF block 
      haplotypes do not align with a single MHC AH and associations often vary with 
      ethnicity. This suggests more recent recombination events between the TNF block 
      and the HLA alleles.
FAU - Valente, F P
AU  - Valente FP
AD  - School of Bioinformatics, University of Paris Diderot, Paris, France.
FAU - Tan, C
AU  - Tan C
FAU - Phipps, M
AU  - Phipps M
FAU - Witt, C S
AU  - Witt CS
FAU - Kaur, G
AU  - Kaur G
FAU - Gut, I
AU  - Gut I
FAU - Allcock, R
AU  - Allcock R
FAU - Price, P
AU  - Price P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090421
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (TNF protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Alleles
MH  - Asian People/genetics
MH  - Conserved Sequence
MH  - Gene Frequency/*genetics
MH  - Genotype
MH  - Haplotypes/genetics
MH  - Humans
MH  - Major Histocompatibility Complex/*genetics
MH  - Native Hawaiian or Other Pacific Islander/genetics
MH  - Polymorphism, Single Nucleotide
MH  - Tumor Necrosis Factor-alpha/*genetics
MH  - White People/genetics
EDAT- 2009/04/28 09:00
MHDA- 2009/08/22 09:00
CRDT- 2009/04/28 09:00
PHST- 2009/04/28 09:00 [entrez]
PHST- 2009/04/28 09:00 [pubmed]
PHST- 2009/08/22 09:00 [medline]
AID - TAN1258 [pii]
AID - 10.1111/j.1399-0039.2009.01258.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2009 Jul;74(1):57-61. doi: 10.1111/j.1399-0039.2009.01258.x. 
      Epub 2009 Apr 21.