PMID- 19392797
OWN - NLM
STAT- MEDLINE
DCOM- 20090821
LR  - 20211020
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 74
IP  - 1
DP  - 2009 Jul
TI  - TNF, LTA and TGFB1 genotype distributions among acute graft-vs-host disease 
      subsets after HLA-matched unrelated hematopoietic stem cell transplantation: a 
      pilot study.
PG  - 50-6
LID - 10.1111/j.1399-0039.2009.01257.x [doi]
AB  - Cytokine single nucleotide polymorphisms and consequent production levels have 
      been associated with acute graft-vs-host disease (aGVHD) development. The aim of 
      this pilot study was to determine whether polymorphisms in tumor necrosis factor 
      (TNF), lymphotoxin alpha (LTA) and transforming growth factor beta 1 (TGFB1) 
      showed any association with aGVHD severity. Novel alleles and polymorphisms were 
      identified for each cytokine locus. Genotype distributions were examined in 38 
      recipient-donor pairs (all chronic myelogenous leukemia in the first chronic 
      phase) with either low-grade (grades 0-I) or high-grade (grades III-IV) aGVHD. 
      Although no significant differences were found, some trends were noted in 
      genotype distributions among aGVHD-grade groups. Power calculations determined 
      that substantially more pairs would be required to show significant associations 
      in distributions among aGVHD-grade groups.
FAU - Shah, R
AU  - Shah R
AD  - Department of Oncology, Georgetown University Medical Center, Washington, DC 
      20057, USA.
FAU - Selby, S T
AU  - Selby ST
FAU - Yokley, B
AU  - Yokley B
FAU - Slack, R S
AU  - Slack RS
FAU - Hurley, C K
AU  - Hurley CK
FAU - Posch, P E
AU  - Posch PE
LA  - eng
GR  - U24 CA076518/CA/NCI NIH HHS/United States
GR  - U24 CA076518-02/CA/NCI NIH HHS/United States
GR  - 240-97-0036/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20090408
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Lymphotoxin-alpha)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Gene Frequency/*genetics
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Graft vs Host Disease/*genetics
MH  - Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Lymphotoxin-alpha/*genetics
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Promoter Regions, Genetic
MH  - Transforming Growth Factor beta1/*genetics
MH  - Tumor Necrosis Factor-alpha/*genetics
MH  - Young Adult
PMC - PMC3215084
MID - NIHMS324827
EDAT- 2009/04/28 09:00
MHDA- 2009/08/22 09:00
PMCR- 2011/11/14
CRDT- 2009/04/28 09:00
PHST- 2009/04/28 09:00 [entrez]
PHST- 2009/04/28 09:00 [pubmed]
PHST- 2009/08/22 09:00 [medline]
PHST- 2011/11/14 00:00 [pmc-release]
AID - TAN1257 [pii]
AID - 10.1111/j.1399-0039.2009.01257.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2009 Jul;74(1):50-6. doi: 10.1111/j.1399-0039.2009.01257.x. Epub 
      2009 Apr 8.