PMID- 19392799
OWN - NLM
STAT- MEDLINE
DCOM- 20090821
LR  - 20090615
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 74
IP  - 1
DP  - 2009 Jul
TI  - MHC class I chain-related gene A transmembrane polymorphism in Spanish women with 
      breast cancer.
PG  - 46-9
LID - 10.1111/j.1399-0039.2009.01254.x [doi]
AB  - The NKG2D-major histocompatibility complex class I-related chain A (MICA) system 
      plays a key role in the antitumoral immune response. We studied five alleles of a 
      microsatellite in the MICA transmembrane region; one of which (MICA-A5.1) gives 
      rise to a truncated protein. The MICA-A5 allele was reduced in breast cancer 
      patients compared with healthy controls (P = 0.04). Given the association between 
      the HLA-B7 allele and the susceptibility to breast cancer in our area, we also 
      analyzed the distribution of the frequency of the MICA alleles in human leukocyte 
      antigen (HLA)-B7 patients compared with patients with the other alleles. The 
      MICA-A5.1 allele was increased in HLA-B7 patients (P = 0.0003). These results 
      suggest that the MICA-A5 allele appears to confer protection against human breast 
      cancer and that the MICA-A5.1 appears to increase the susceptibility to breast 
      cancer in HLA-B7 patients in our area.
FAU - Lavado-Valenzuela, R
AU  - Lavado-Valenzuela R
AD  - Immunology Service, Carlos Haya Regional University Hospital, Malaga, Spain. 
      rocio.lavado@fundacionimabis.org
FAU - Benavides, M
AU  - Benavides M
FAU - Carabantes, F
AU  - Carabantes F
FAU - Alonso, A
AU  - Alonso A
FAU - Caballero, A
AU  - Caballero A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090408
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-B7 Antigen)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (MHC class I-related chain A)
SB  - IM
MH  - Alleles
MH  - Breast Neoplasms/epidemiology/*genetics
MH  - Exons/genetics
MH  - Female
MH  - Gene Frequency/*genetics
MH  - Genetic Predisposition to Disease
MH  - HLA-B7 Antigen/*genetics
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Microsatellite Repeats/*genetics
MH  - Polymorphism, Genetic
MH  - Spain/epidemiology
EDAT- 2009/04/28 09:00
MHDA- 2009/08/22 09:00
CRDT- 2009/04/28 09:00
PHST- 2009/04/28 09:00 [entrez]
PHST- 2009/04/28 09:00 [pubmed]
PHST- 2009/08/22 09:00 [medline]
AID - TAN1254 [pii]
AID - 10.1111/j.1399-0039.2009.01254.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2009 Jul;74(1):46-9. doi: 10.1111/j.1399-0039.2009.01254.x. Epub 
      2009 Apr 8.