PMID- 19392802
OWN - NLM
STAT- MEDLINE
DCOM- 20090810
LR  - 20221207
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 73
IP  - 6
DP  - 2009 Jun
TI  - The association between HLA-A, -B alleles and major histocompatibility complex 
      class I polymorphic Alu insertions in four populations in China.
PG  - 575-81
LID - 10.1111/j.1399-0039.2009.01251.x [doi]
AB  - The study of the association between polymorphic Alu insertions [human leukocyte 
      antigen (HLA)-Alu] at five loci and HLA class I alleles at two loci allows for 
      better identification of the origins and evolution of HLA class I region 
      haplotypes in different populations. In the present study, we determined the 
      frequencies of five HLA-Alus and their associations with HLA-A and -B alleles in 
      Han, Wa, Maonan, and Jinuo populations. Our results showed a strong association 
      between AluHG insertion and HLA-A*02 in all populations studied; however, the 
      associations between AluHJ insertion and HLA-A*1101 and HLA-A*2402 and AluHF 
      insertion and HLA-A*2601 were only observed in Han. The AluMICB insertion showed 
      a strong association with HLA-B*5502 in Han, Maonan, and Jinuo. HLA-A*0101, 
      HLA-A*0201, HLA-A*0203, HLA-A*1101, HLA-A*2402, HLA-A*2601, and HLA-A*3101 
      alleles were associated with one or more of the three different Alu elements 
      within the alpha block as independent haplotypes, and HLA-A*0101, HLA-A*0201, 
      HLA-A*0203, HLA-A*1101, and HLA-A*2402 alleles were associated with at least two 
      different Alu insertions as a haplotype within the alpha block. We conclude that 
      the HLA class I region haplotypes of the four populations were derived from 
      different progenitor haplotypes, and relatively high rates of recombination 
      between individuals with HLA-A alleles and different HLA-Alus occurred in this 
      region.
FAU - Yao, Y
AU  - Yao Y
AD  - Department of Medical Genetics, Institute of Medical Biology, Chinese Academy of 
      Medical Sciences & Peking Union Medical College, Kunming, China.
FAU - Shi, L
AU  - Shi L
FAU - Shi, L
AU  - Shi L
FAU - Lin, K
AU  - Lin K
FAU - Yu, L
AU  - Yu L
FAU - Sun, H
AU  - Sun H
FAU - Huang, X
AU  - Huang X
FAU - Tao, Y
AU  - Tao Y
FAU - Yi, W
AU  - Yi W
FAU - Liu, S
AU  - Liu S
FAU - Chu, J
AU  - Chu J
LA  - eng
PT  - Journal Article
DEP - 20090406
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
SB  - IM
EIN - Tissue Antigens. 2009 Aug;74(2):187
MH  - Alleles
MH  - Alu Elements/*genetics
MH  - Asian People/genetics
MH  - China
MH  - Gene Frequency/*genetics
MH  - Genetics, Population
MH  - Genotype
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - Haplotypes/genetics
MH  - Humans
MH  - Polymorphism, Genetic
EDAT- 2009/04/28 09:00
MHDA- 2009/08/11 09:00
CRDT- 2009/04/28 09:00
PHST- 2009/04/28 09:00 [entrez]
PHST- 2009/04/28 09:00 [pubmed]
PHST- 2009/08/11 09:00 [medline]
AID - TAN1251 [pii]
AID - 10.1111/j.1399-0039.2009.01251.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2009 Jun;73(6):575-81. doi: 10.1111/j.1399-0039.2009.01251.x. 
      Epub 2009 Apr 6.