PMID- 19392807
OWN - NLM
STAT- MEDLINE
DCOM- 20090810
LR  - 20211020
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 73
IP  - 6
DP  - 2009 Jun
TI  - Evaluating the potential impact of mismatches outside the antigen recognition 
      site in unrelated hematopoietic stem cell transplantation: HLA-DRB1*1454 and 
      DRB1*140101.
PG  - 595-8
LID - 10.1111/j.1399-0039.2009.01245.x [doi]
AB  - DNA sequencing of 268 individuals drawn from four US populations carrying two 
      unresolved DRB1*14 alleles differing only outside the antigen recognition site 
      identified DRB1*1454 in the majority. A database of 4222 human leukocyte antigen 
      (HLA)-matched hematopoietic stem cell transplantation donor-recipient pairs was 
      queried to determine the number likely mismatched for DRB1*140101/DRB1*1454 but 
      matched for class I loci. A power calculation suggests that more than 88,000 
      transplants among European Americans will be needed to identify sufficient 7/8 
      allele-matched pairs to evaluate the impact of the DRB1*140101/DRB1*1454 mismatch 
      on transplant outcome. Molecular modeling of the HLA-DR interaction with the 
      T-cell receptor and with CD4 suggests that the amino acid substitution 
      distinguishing the two alleles will have minimal impact on allorecognition.
FAU - Xiao, Y
AU  - Xiao Y
AD  - Department of Pediatrics and Oncology, C.W. Bill Young Marrow Donor Research and 
      Recruitment Program, Georgetown University Medical Center, Washington, DC 20057, 
      USA.
FAU - Lazaro, A M
AU  - Lazaro AM
FAU - Masaberg, C
AU  - Masaberg C
FAU - Haagenson, M
AU  - Haagenson M
FAU - Vierra-Green, C
AU  - Vierra-Green C
FAU - Spellman, S
AU  - Spellman S
FAU - Dakshanamurthy, S
AU  - Dakshanamurthy S
FAU - Ng, J
AU  - Ng J
FAU - Hurley, C K
AU  - Hurley CK
LA  - eng
GR  - U24 CA076518/CA/NCI NIH HHS/United States
GR  - U24 CA076518-05/CA/NCI NIH HHS/United States
GR  - U24-CA76518/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20090406
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (CD4 Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*14:01 antigen)
RN  - 0 (HLA-DRB1*14:54 antigen)
SB  - IM
MH  - Alleles
MH  - Amino Acid Substitution/genetics
MH  - *Base Pair Mismatch
MH  - CD4 Antigens/chemistry/immunology/metabolism
MH  - DNA Mutational Analysis
MH  - Gene Frequency/*genetics
MH  - HLA-DR Antigens/chemistry/*genetics
MH  - HLA-DRB1 Chains
MH  - Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Polymorphism, Genetic
MH  - Retrospective Studies
PMC - PMC3224974
MID - NIHMS324828
EDAT- 2009/04/28 09:00
MHDA- 2009/08/11 09:00
PMCR- 2011/11/28
CRDT- 2009/04/28 09:00
PHST- 2009/04/28 09:00 [entrez]
PHST- 2009/04/28 09:00 [pubmed]
PHST- 2009/08/11 09:00 [medline]
PHST- 2011/11/28 00:00 [pmc-release]
AID - TAN1245 [pii]
AID - 10.1111/j.1399-0039.2009.01245.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2009 Jun;73(6):595-8. doi: 10.1111/j.1399-0039.2009.01245.x. 
      Epub 2009 Apr 6.