PMID- 19392835
OWN - NLM
STAT- MEDLINE
DCOM- 20090810
LR  - 20090605
IS  - 1744-313X (Electronic)
IS  - 1744-3121 (Linking)
VI  - 36
IP  - 3
DP  - 2009 Jun
TI  - The combination of polymorphisms within MCP-1 and IL-1beta associated with 
      ulcerative colitis.
PG  - 135-9
LID - 10.1111/j.1744-313X.2009.00836.x [doi]
AB  - Monocyte chemoattractant protein-1 (MCP-1) is a chemokine involved in monocyte 
      recruitment to sites of inflammation. Raised level of MCP-1 has been widely 
      demonstrated in the intestinal mucosa of patients with ulcerative colitis (UC), 
      suggesting an important role of MCP-1 in the pathogenesis of UC. The -2518A/G 
      polymorphism in the promoter region of MCP-1 gene affecting its transcriptional 
      activation has been reported recently. In order to assess the potential role of 
      this polymorphism in UC, we examined its distribution in 162 unrelated UC 
      patients and 203 healthy controls. In addition, considering the gene regulatory 
      association between interleukin-1beta (IL-1beta) and MCP-1, we further examined 
      whether the gene polymorphisms between MCP-1 and IL-1beta exert synergetic 
      effects on risk of UC. Our results show that the distribution of MCP-1 genotype 
      or allele frequencies between UC patients and controls was not significantly 
      different; however, the association between the polymorphism of MCP-1 -2518 GG 
      and the polymorphism of IL-1beta-511 T in UC patients is significant (OR 2.062, 
      95% CI 1.034-4.113, P = 0.038). This is the first report describing the 
      association between MCP-1 polymorphism and UC, and our data suggest that the 
      MCP-1 -2518 polymorphism itself does not represent an independent genetic risk 
      factor for UC. In contrast, the combination polymorphisms between MCP-1 and 
      IL-1beta can increase UC risk significantly, which might help us understand the 
      molecular mechanism underlying the development of UC.
FAU - Li, K-S
AU  - Li KS
AD  - Department of Biomedical Engineering, Harbin Engineering University, Harbin, 
      China.
FAU - Wang, B-Y
AU  - Wang BY
FAU - Liu, S-Y
AU  - Liu SY
FAU - Yao, S-P
AU  - Yao SP
FAU - Guo, L
AU  - Guo L
FAU - Mao, D-W
AU  - Mao DW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Immunogenet
JT  - International journal of immunogenetics
JID - 101232337
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-1beta)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Chemokine CCL2/*genetics
MH  - Colitis, Ulcerative/*genetics
MH  - Female
MH  - Gene Frequency/*genetics
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Interleukin-1beta/*genetics
MH  - Intestinal Mucosa/metabolism
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Promoter Regions, Genetic
MH  - Young Adult
EDAT- 2009/04/28 09:00
MHDA- 2009/08/11 09:00
CRDT- 2009/04/28 09:00
PHST- 2009/04/28 09:00 [entrez]
PHST- 2009/04/28 09:00 [pubmed]
PHST- 2009/08/11 09:00 [medline]
AID - EJI836 [pii]
AID - 10.1111/j.1744-313X.2009.00836.x [doi]
PST - ppublish
SO  - Int J Immunogenet. 2009 Jun;36(3):135-9. doi: 10.1111/j.1744-313X.2009.00836.x.