PMID- 19392852
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20221207
IS  - 1442-2050 (Electronic)
IS  - 1120-8694 (Linking)
VI  - 23
IP  - 1
DP  - 2010 Jan
TI  - Polymorphisms of HLA-A and HLA-B genes in genetic susceptibility to esophageal 
      carcinoma in Chaoshan Han Chinese.
PG  - 46-52
LID - 10.1111/j.1442-2050.2009.00965.x [doi]
AB  - Esophageal carcinoma (EC) occurs at high rate in Chaoshan region of southern 
      China. Human leukocyte antigen (HLA) polymorphism has been implicated in risk for 
      various cancers. To investigate the impact of HLA-A and HLA-B polymorphisms on 
      susceptibility to EC, a case-control study was conducted among 206 patients with 
      esophageal squamous cell carcinoma and 524 controls from Chaoshan Han population. 
      HLA-A and HLA-B polymorphisms were genotyped by polymerase chain 
      reaction-sequence-specific primers. Genotypic association tests for dominant, 
      recessive, and additive models, and haplotypic association were calculated using 
      unconditional logistic regression. A*11 was identified in a recessive model as an 
      only allele strongly associated with EC risk (odds ratios [OR]=2.10, 95% 
      confidence interval [CI]=1.33-3.31) even after correction for multiple test. The 
      haplotypes A*02-B*46 (OR=1.53, 95% CI=1.04-2.24) and A*11-B*51 (OR=2.29, 95% 
      CI=1.20-4.40) showed association with increased risk for EC, whereas A*11-B*58 
      (OR=0.00, 95% CI=0.00-0.82) was associated with decreased risk, though the 
      significance of these haplotypes was lost after correction. This is a first 
      association study at genetic level identifying HLA-A and HLA-B-related variations 
      in genetic susceptibility to EC among Chaoshan population. The variation pattern 
      is likely to be EC-specific because it is different from that observed for 
      nasopharyngeal carcinoma in the same study population and might, at least in 
      part, explain the high rate of EC in this ethnic group.
FAU - Hu, Sheng-Ping
AU  - Hu SP
AD  - Department of Thoracic Surgery, First Affiliated Hospital, and Center for 
      Molecular Biology and Forensic Genetics Laboratory, Shantou University Medical 
      College, Shantou, China. sphu@stu.edu.cn
FAU - Zhou, Guang-Biao
AU  - Zhou GB
FAU - Luan, Jian-An
AU  - Luan JA
FAU - Chen, Yu-Ping
AU  - Chen YP
FAU - Xiao, Da-Wei
AU  - Xiao DW
FAU - Deng, Yu-Ju
AU  - Deng YJ
FAU - Huang, Li-Qun
AU  - Huang LQ
FAU - Cai, Ke-Li
AU  - Cai KL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090415
PL  - United States
TA  - Dis Esophagus
JT  - Diseases of the esophagus : official journal of the International Society for 
      Diseases of the Esophagus
JID - 8809160
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - Asian People/genetics
MH  - Carcinoma, Squamous Cell/ethnology/genetics
MH  - Case-Control Studies
MH  - China
MH  - Esophageal Neoplasms/ethnology/*genetics
MH  - Ethnicity/genetics
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - Haplotypes
MH  - Humans
MH  - *Polymorphism, Genetic
EDAT- 2009/04/28 09:00
MHDA- 2010/09/15 06:00
CRDT- 2009/04/28 09:00
PHST- 2009/04/28 09:00 [entrez]
PHST- 2009/04/28 09:00 [pubmed]
PHST- 2010/09/15 06:00 [medline]
AID - DES965 [pii]
AID - 10.1111/j.1442-2050.2009.00965.x [doi]
PST - ppublish
SO  - Dis Esophagus. 2010 Jan;23(1):46-52. doi: 10.1111/j.1442-2050.2009.00965.x. Epub 
      2009 Apr 15.