PMID- 19392871
OWN - NLM
STAT- MEDLINE
DCOM- 20100222
LR  - 20220309
IS  - 1365-2036 (Electronic)
IS  - 0269-2813 (Linking)
VI  - 30
IP  - 2
DP  - 2009 Jul 1
TI  - Comparison of risk factors and clinical responses to proton pump inhibitors in 
      patients with erosive oesophagitis and non-erosive reflux disease.
PG  - 154-64
LID - 10.1111/j.1365-2036.2009.04021.x [doi]
AB  - BACKGROUND: There has been no report on the response to proton pump inhibitor 
      (PPI) therapy and on-demand or the relapse rate of non-erosive reflux disease 
      (NERD) and erosive oesophagitis in Korea. AIM: To compare the risk factors, 
      clinical symptoms and PPI responses between patients with erosive oesophagitis 
      and NERD patients. METHODS: A survey was performed prospectively in the erosive 
      oesophagitis (205 patients) and NERD group (200 patients). Clinical symptoms, 
      risk factors and PPI responses were analysed. On-demand therapy and the relapse 
      rate of GERD symptoms were investigated during a one-year follow-up. RESULTS: BMI 
      > or = 25 (OR 3.0, 95% CI 1.1-8.3), alcohol use (OR 2.9, 95% CI 1.0-8.3), hiatal 
      hernia (OR 5.0, 95% CI 1.2-20) and triglyceride > or =150 mg/dL (OR 4.0, 95% CI 
      1.7-10) were more common in the erosive oesophagitis group than in the NERD group 
      by multivariate analysis. The ratio of oesophageal to extra-oesophageal symptoms 
      was higher in the erosive oesophagitis group compared with the NERD group (P < 
      0.001). The PPI response rates at 8 weeks were different (P = 0.02); refractory 
      rates were higher in the NERD group (16.7%) compared with the erosive 
      oesophagitis group (6.0%). However, there was no significant difference between 
      the two groups in on-demand therapy or the relapse rate. CONCLUSION: These 
      results suggest that the underlying pathogenic mechanisms of erosive oesophagitis 
      and NERD are distinct.
FAU - Lee, E S
AU  - Lee ES
AD  - Department of Internal Medicine, Seoul National University Bundang Hospital, 
      Seongnam 463-707, Korea.
FAU - Kim, N
AU  - Kim N
FAU - Lee, S H
AU  - Lee SH
FAU - Park, Y S
AU  - Park YS
FAU - Kim, J W
AU  - Kim JW
FAU - Jeong, S H
AU  - Jeong SH
FAU - Lee, D H
AU  - Lee DH
FAU - Jung, H C
AU  - Jung HC
FAU - Song, I S
AU  - Song IS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20090415
PL  - England
TA  - Aliment Pharmacol Ther
JT  - Alimentary pharmacology & therapeutics
JID - 8707234
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Ulcer Agents/*therapeutic use
MH  - Esophagitis/*drug therapy/epidemiology
MH  - Female
MH  - Gastroesophageal Reflux/*drug therapy/epidemiology
MH  - Humans
MH  - Korea/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Risk Factors
MH  - Secondary Prevention
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2009/04/28 09:00
MHDA- 2010/02/23 06:00
CRDT- 2009/04/28 09:00
PHST- 2009/04/28 09:00 [entrez]
PHST- 2009/04/28 09:00 [pubmed]
PHST- 2010/02/23 06:00 [medline]
AID - APT4021 [pii]
AID - 10.1111/j.1365-2036.2009.04021.x [doi]
PST - ppublish
SO  - Aliment Pharmacol Ther. 2009 Jul 1;30(2):154-64. doi: 
      10.1111/j.1365-2036.2009.04021.x. Epub 2009 Apr 15.