PMID- 19394173
OWN - NLM
STAT- MEDLINE
DCOM- 20100427
LR  - 20131121
IS  - 1872-7131 (Electronic)
IS  - 0387-7604 (Linking)
VI  - 32
IP  - 3
DP  - 2010 Mar
TI  - Effects of antiepileptic drugs on mRNA levels of BDNF and NT-3 and cell 
      neogenesis in the developing rat brain.
PG  - 229-35
LID - 10.1016/j.braindev.2009.03.012 [doi]
AB  - Epilepsy is a common neurological disorder that occurs more frequently in 
      childhood than in adulthood. Antiepileptic drugs (AEDs) which are used to treat 
      seizures in pregnant women, infants, and young children may cause cognitive 
      impairment or other uncertain injury. However, the exact mechanisms responsible 
      for adverse effects of AEDs in the developing brain are still not clear. In the 
      present study, we investigate the effects of AEDs on mRNA levels of brain-derived 
      neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), cell neogenesis and mossy 
      fiber sprouting (MFS) in the developing rat brain. Long-term treatment with 
      Phenobarbital (40mg/kg), valproate (100mg/kg) and topiramate (40mg/kg) reduces 
      BDNF and NT-3 mRNA expression in the developing brain, while lamotrigine reduces 
      mRNA expression only at high dose level (80mg/kg). Cell neogenesis only increases 
      in the rats treated with valproate and lamotrigine. And no differences are 
      observed between the control group and the AEDs-treated groups in the Timm scores 
      of the CA3 region and supragranular region. Our findings present some possible 
      mechanisms to explain why different AEDs cause different cognitive impairment.
FAU - Shi, Xiu-Yu
AU  - Shi XY
AD  - Department of Pediatrics, Beijing Friendship Hospital, Capital Medical 
      University, Beijing 100050, PR China.
FAU - Wang, Ji-Wen
AU  - Wang JW
FAU - Cui, Hong
AU  - Cui H
FAU - Li, Bao-Min
AU  - Li BM
FAU - Lei, Ge-Fei
AU  - Lei GF
FAU - Sun, Ruo-Peng
AU  - Sun RP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090424
PL  - Netherlands
TA  - Brain Dev
JT  - Brain & development
JID - 7909235
RN  - 0 (Anticonvulsants)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neurotrophin 3)
RN  - 0 (RNA, Messenger)
RN  - G34N38R2N1 (Bromodeoxyuridine)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Newborn
MH  - Anticonvulsants/*pharmacology
MH  - *Brain/drug effects/growth & development/pathology
MH  - Brain-Derived Neurotrophic Factor/*genetics/metabolism
MH  - Bromodeoxyuridine/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Gene Expression Regulation/drug effects
MH  - Mossy Fibers, Hippocampal/drug effects/metabolism
MH  - Neurogenesis/*drug effects
MH  - Neurotrophin 3/*genetics/metabolism
MH  - RNA, Messenger/*metabolism
MH  - Rats
MH  - Rats, Wistar
EDAT- 2009/04/28 09:00
MHDA- 2010/04/28 06:00
CRDT- 2009/04/28 09:00
PHST- 2009/02/09 00:00 [received]
PHST- 2009/03/14 00:00 [revised]
PHST- 2009/03/27 00:00 [accepted]
PHST- 2009/04/28 09:00 [entrez]
PHST- 2009/04/28 09:00 [pubmed]
PHST- 2010/04/28 06:00 [medline]
AID - S0387-7604(09)00095-3 [pii]
AID - 10.1016/j.braindev.2009.03.012 [doi]
PST - ppublish
SO  - Brain Dev. 2010 Mar;32(3):229-35. doi: 10.1016/j.braindev.2009.03.012. Epub 2009 
      Apr 24.