PMID- 19395784
OWN - NLM
STAT- MEDLINE
DCOM- 20090804
LR  - 20151119
IS  - 1735-8582 (Print)
IS  - 1735-8582 (Linking)
VI  - 3
IP  - 2
DP  - 2009 Apr
TI  - Diagnostic potential of urinary tumor necrosis factor-alpha in children with 
      acute pyelonephritis.
PG  - 89-92
AB  - INTRODUCTION: Tumor necrosis factor-alpha (TNF-alpha) is an important mediator of 
      the inflammatory response in serious bacterial infections. The aim of this study 
      was to evaluate the potential of urinary TNF-alpha for diagnosis of acute 
      pyelonephritis in children. MATERIALS AND METHODS: This study was conducted from 
      March 2006 to December 2007 on children with confirmed diagnosis of acute 
      pyelonephritis. They all had positive renal scintigraphy scans for pyelonephritis 
      and leukocyturia. The ratios of urinary TNF-alpha to urine creatinine level were 
      determined and compared in patients before and after antibiotic therapy. RESULTS: 
      Eighty-two children (13 boys and 69 girls) with acute pyelonephritis were 
      evaluated. The mean pretreatment ratio of urinary TNF-alpha to urinary creatinine 
      level was higher than that 3 days after starting on empirical treatment (P = 
      .03). The sensitivity of this parameter was 91% for diagnosis of acute 
      pyelonephritis when compared with demercaptosuccinic acid renal scintigraphy as 
      gold standard. CONCLUSIONS: Based on our findings in children, the level of 
      urinary TNF-alpha-creatinine ratio is acute increased in pyelonephritis and it 
      decreases after appropriate therapy with a high sensitivity for early diagnosis 
      of the disease. Further research is warranted for shedding light on the potential 
      diagnostic role of urinary TNF-alpha in pyelonephritis in children.
FAU - Mohkam, Masoumeh
AU  - Mohkam M
AD  - Pediatric Infectious Research Center, Shahid Beheshti University (MC), Tehran, 
      Iran. mohkamm@yahoo.com
FAU - Asgarian, Fahimeh
AU  - Asgarian F
FAU - Fahimzad, Alireza
AU  - Fahimzad A
FAU - Sharifian, Mostafa
AU  - Sharifian M
FAU - Dalirani, Reza
AU  - Dalirani R
FAU - Abdollah Gorgi, Fatemeh
AU  - Abdollah Gorgi F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Iran
TA  - Iran J Kidney Dis
JT  - Iranian journal of kidney diseases
JID - 101316967
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Biomarkers)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 75J73V1629 (Ceftriaxone)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Acute Disease
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Biomarkers/urine
MH  - Ceftriaxone/therapeutic use
MH  - Child, Preschool
MH  - Creatinine/urine
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Pyelonephritis/*diagnosis/drug therapy
MH  - Tumor Necrosis Factor-alpha/*urine
EDAT- 2009/04/28 09:00
MHDA- 2009/08/06 09:00
CRDT- 2009/04/28 09:00
PHST- 2009/04/28 09:00 [entrez]
PHST- 2009/04/28 09:00 [pubmed]
PHST- 2009/08/06 09:00 [medline]
AID - 113/96 [pii]
PST - ppublish
SO  - Iran J Kidney Dis. 2009 Apr;3(2):89-92.