PMID- 19396405
OWN - NLM
STAT- MEDLINE
DCOM- 20110608
LR  - 20131121
IS  - 1559-0720 (Electronic)
IS  - 0163-4984 (Linking)
VI  - 132
IP  - 1-3
DP  - 2009 Dec
TI  - Effects of N-acetylcysteine, deferoxamine and selenium on doxorubicin-induced 
      hepatotoxicity.
PG  - 184-96
LID - 10.1007/s12011-009-8377-y [doi]
AB  - The aims of our study were to evaluate the antioxidant defence mechanisms of 
      liver tissue challenged by doxorubucin (DOX) and to compare the possible 
      protective effects of N-acetylcysteine (NAC) (n=10), deferoxamine (DOF) (n=10), 
      DOF+NAC (n= 10) and selenium (n=9) on doxorubicin-induced hepatotoxicity. 
      Fifty-six male rats (Mean weight = 250 +/- 50 g) randomly divided into five groups. 
      Animals in study groups were pretreated with a single dose of Dox, which was 
      administered intravenously. Control group (n=7) was treated with intravenous 
      saline injection. Selenium was given intraperitoneally. Blood and urine samples 
      were collected before sacrifice. Liver tissue samples were collected and tissue 
      superoxide dismutase (SOD), glutathione peroxidase (GSH-px), CAT activity, MDA, 
      Zn, iron and copper were determined. DFO decreased lipid peroxidation 
      significantly. DFO and NAC decreased CAT activity significantly. Antioxidant 
      regimes increase SOD activities significantly. DOF and NAC increase GSH-px 
      activities and copper levels significantly. Beneficial effect of selenium seems 
      to result from its stimulation of SOD but not to GSH-px. It has been found that 
      DOF, NAC and selenium have protective effects on Dox-induced hepatocellular 
      damage. DOF+NAC did not result additional benefit.
FAU - Bulucu, Fatih
AU  - Bulucu F
AD  - Department of Internal Medicine, Gulhane Military Medical Academy, Ankara, 
      Turkey.
FAU - Ocal, Ramazan
AU  - Ocal R
FAU - Karadurmus, Nuri
AU  - Karadurmus N
FAU - Sahin, Mustafa
AU  - Sahin M
FAU - Kenar, Levent
AU  - Kenar L
FAU - Aydin, Ahmet
AU  - Aydin A
FAU - Oktenli, Cagatay
AU  - Oktenli C
FAU - Koc, Bayram
AU  - Koc B
FAU - Inal, Volkan
AU  - Inal V
FAU - Yamanel, Levent
AU  - Yamanel L
FAU - Yaman, Halil
AU  - Yaman H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Biol Trace Elem Res
JT  - Biological trace element research
JID - 7911509
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 789U1901C5 (Copper)
RN  - 80168379AG (Doxorubicin)
RN  - E1UOL152H7 (Iron)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - H6241UJ22B (Selenium)
RN  - J06Y7MXW4D (Deferoxamine)
RN  - J41CSQ7QDS (Zinc)
RN  - WYQ7N0BPYC (Acetylcysteine)
SB  - IM
MH  - Acetylcysteine/*pharmacology
MH  - Animals
MH  - Catalase/metabolism
MH  - Copper/metabolism
MH  - Deferoxamine/*pharmacology
MH  - Doxorubicin/*toxicity
MH  - Glutathione Peroxidase/metabolism
MH  - Iron/metabolism
MH  - Lipid Peroxidation/drug effects
MH  - Liver/*drug effects/*metabolism
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Selenium/*pharmacology
MH  - Superoxide Dismutase/metabolism
MH  - Zinc/metabolism
EDAT- 2009/04/28 09:00
MHDA- 2011/06/09 06:00
CRDT- 2009/04/28 09:00
PHST- 2009/02/27 00:00 [received]
PHST- 2009/04/06 00:00 [accepted]
PHST- 2009/04/28 09:00 [entrez]
PHST- 2009/04/28 09:00 [pubmed]
PHST- 2011/06/09 06:00 [medline]
AID - 10.1007/s12011-009-8377-y [doi]
PST - ppublish
SO  - Biol Trace Elem Res. 2009 Dec;132(1-3):184-96. doi: 10.1007/s12011-009-8377-y.