PMID- 19398075
OWN - NLM
STAT- MEDLINE
DCOM- 20100222
LR  - 20220318
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Linking)
VI  - 15
IP  - 4
DP  - 2009 May
TI  - Depression and disease severity as predictors of health-related quality of life 
      in patients with chronic heart failure--a structural equation modeling approach.
PG  - 286-292.e2
LID - 10.1016/j.cardfail.2008.10.022 [doi]
AB  - BACKGROUND: To examine whether depression and heart failure severity are 
      independent predictors of both the physical and psychologic domains of 
      health-related quality of life (HRQoL) in patients with chronic heart failure. 
      METHODS AND RESULTS: A sample of 206 outpatients with chronic heart failure (mean 
      age 64 years, 69% male) was evaluated. Depression was measured with the Patient 
      Health Questionnaire and disease-specific HRQoL with the Kansas City 
      Cardiomyopathy Questionnaire. Heart failure severity was assessed with physician 
      ratings of the New York Heart Association (NYHA) functional class. The 
      simultaneous effects of predictor variables on outcomes were estimated using 
      structural equation modeling. Both depression and NYHA functional class 
      independently predicted the physical domain of HRQoL. By contrast, the 
      psychologic domain was only predicted by depression, but not by NYHA functional 
      class. CONCLUSIONS: Our results suggest that comorbid depression has an 
      independent impact on both physical and psychologic HRQoL in patients with 
      chronic heart failure after controlling for the severity of heart failure 
      symptoms, while heart failure severity only impacts physical HRQoL. Thus, 
      assessment of comorbid depression may help interpreting reduced HRQoL in heart 
      failure patients. Research seems warranted evaluating whether the amelioration of 
      depression may enhance patients' HRQoL in chronic heart failure.
FAU - Faller, Hermann
AU  - Faller H
AD  - Institute of Psychotherapy und Medical Psychology, University of Wurzburg, 
      Wurzburg, Germany. h.faller@uni-wuerzburg.de
FAU - Stork, Stefan
AU  - Stork S
FAU - Schuler, Michael
AU  - Schuler M
FAU - Schowalter, Marion
AU  - Schowalter M
FAU - Steinbuchel, Thomas
AU  - Steinbuchel T
FAU - Ertl, Georg
AU  - Ertl G
FAU - Angermann, Christiane E
AU  - Angermann CE
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081225
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
SB  - IM
MH  - Chronic Disease
MH  - Depressive Disorder/physiopathology/*psychology
MH  - Female
MH  - Heart Failure/physiopathology/*psychology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Models, Theoretical
MH  - Predictive Value of Tests
MH  - Quality of Life/*psychology
MH  - *Severity of Illness Index
EDAT- 2009/04/29 09:00
MHDA- 2010/02/23 06:00
CRDT- 2009/04/29 09:00
PHST- 2008/05/26 00:00 [received]
PHST- 2008/10/16 00:00 [revised]
PHST- 2008/10/20 00:00 [accepted]
PHST- 2009/04/29 09:00 [entrez]
PHST- 2009/04/29 09:00 [pubmed]
PHST- 2010/02/23 06:00 [medline]
AID - S1071-9164(08)01046-4 [pii]
AID - 10.1016/j.cardfail.2008.10.022 [doi]
PST - ppublish
SO  - J Card Fail. 2009 May;15(4):286-292.e2. doi: 10.1016/j.cardfail.2008.10.022. Epub 
      2008 Dec 25.