PMID- 19398084
OWN - NLM
STAT- MEDLINE
DCOM- 20100222
LR  - 20090428
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Linking)
VI  - 15
IP  - 4
DP  - 2009 May
TI  - Value of the paced QRS duration.
PG  - 347-52
LID - 10.1016/j.cardfail.2008.11.008 [doi]
AB  - BACKGROUND: The value for paced QRS duration (pQRSd) to detect left ventricular 
      (LV) dysfunction in right ventricular apex (RVA)-paced patients has not been 
      evaluated. METHODS AND RESULTS: A total of 272 RVA-paced patients, including 99 
      with LV systolic dysfunction (LVSD) and 173 without LVSD, were enrolled in this 
      study. The pQRSd, echocardiographic variables, and plasma N-terminal pro-brain 
      natriuretic peptide (NT-proBNP) levels were measured. Relationships between pQRSd 
      and echocardiographic variables, NT-proBNP levels, and New York Heart Association 
      (NYHA) functional classification were analyzed. pQRSd was correlated with LV 
      end-diastolic and end-systolic dimensions (beta = 1.59 and 1.54, respectively; 
      all P < .001), NT-proBNP levels (beta = 12.98, P < .001) and LV ejection fraction 
      (beta = -109.25, P < .001). There was a stepwise increase in pQRSd with 
      increasing NYHA Class (all P < .001). The pQRSd cutoff value of 200 ms, derived 
      from the receiver operator characteristic curve, had sensitivity of 71.72% and 
      specificity of 86.71% to detect LVSD. pQRSd >or= 240 ms gave a positive 
      predictive value of 100%, whereas <180 ms excluded >97.3% of patients with LVSD. 
      CONCLUSIONS: In RVA-paced patients, pQRSd is correlated with left ventricular 
      structures and function and pQRSd of 200 ms is a satisfactory cutoff value in 
      terms of sensitivity and specificity for detecting LVSD.
FAU - Pan, Wenzhi
AU  - Pan W
AD  - Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, 
      Zhongshan Hospital, Fudan University, Shanghai, China.
FAU - Su, Yangang
AU  - Su Y
FAU - Gong, Xue
AU  - Gong X
FAU - Sun, Aijun
AU  - Sun A
FAU - Shu, Xianhong
AU  - Shu X
FAU - Ge, Junbo
AU  - Ge J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090303
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cardiac Pacing, Artificial/methods/*standards
MH  - Case-Control Studies
MH  - Echocardiography/methods/*standards
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Reference Values
MH  - Sensitivity and Specificity
MH  - Stroke Volume/physiology
MH  - Ventricular Dysfunction, Left/diagnosis/physiopathology
MH  - Ventricular Function, Right/physiology
EDAT- 2009/04/29 09:00
MHDA- 2010/02/23 06:00
CRDT- 2009/04/29 09:00
PHST- 2008/04/25 00:00 [received]
PHST- 2008/11/12 00:00 [revised]
PHST- 2008/11/14 00:00 [accepted]
PHST- 2009/04/29 09:00 [entrez]
PHST- 2009/04/29 09:00 [pubmed]
PHST- 2010/02/23 06:00 [medline]
AID - S1071-9164(08)01087-7 [pii]
AID - 10.1016/j.cardfail.2008.11.008 [doi]
PST - ppublish
SO  - J Card Fail. 2009 May;15(4):347-52. doi: 10.1016/j.cardfail.2008.11.008. Epub 
      2009 Mar 3.