PMID- 19398605
OWN - NLM
STAT- MEDLINE
DCOM- 20090611
LR  - 20090428
IS  - 0091-2700 (Print)
IS  - 0091-2700 (Linking)
VI  - 49
IP  - 5
DP  - 2009 May
TI  - Inflammatory mediators in Chinese patients with congestive heart failure.
PG  - 591-9
LID - 10.1177/0091270009333265 [doi]
AB  - In this study, circulating levels of proinflammatory and anti-inflammatory 
      mediators are studied in patients with chronic heart failure (CHF) in China. 
      Sixty-five patients with CHF and 32 control subjects are studied. The 
      proinflammatory and anti-inflammatory cytokines interleukin (IL)-6, IL-10, tumor 
      necrosis factor (TNF)-alpha, atrial natriuretic peptide (ANP), and brain 
      natriuretic peptide (BNP) in plasma are determined by immunoradiometric assay 
      kits. Catecholamine (CA) in plasma is evaluated by high-performance liquid 
      chromatography. Plasma levels of IL-6, IL-10, TNF-alpha, ANP, BNP, and CA in CHF 
      patients are significantly higher than those in control subjects. Patients in a 
      higher New York Heart Association (NYHA) class show higher concentrations of 
      inflammatory mediators than those in a lower NYHA class, although the ratio of 
      plasma IL-10 to TNF-alpha in patients with CHF is significantly lower than in the 
      control group. It is concluded that proinflammatory and anti-inflammatory 
      cytokine levels are increased and IL-10/TNF-alpha is decreased in Chinese 
      patients with CHF.
FAU - Wang, Yongqing
AU  - Wang Y
AD  - Research Division of Clinical Pharmacology, The First Affiliated Hospital of 
      Nanjing Medical University, Nanjing, China. wangyq999@yahoo.com.cn
FAU - Zhou, Yanli
AU  - Zhou Y
FAU - Meng, Ling
AU  - Meng L
FAU - Lu, Xinzheng
AU  - Lu X
FAU - Ou, Ning
AU  - Ou N
FAU - Li, Xinli
AU  - Li X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Clin Pharmacol
JT  - Journal of clinical pharmacology
JID - 0366372
RN  - 0 (Catecholamines)
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 130068-27-8 (Interleukin-10)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
SB  - IM
MH  - Atrial Natriuretic Factor/blood
MH  - Catecholamines/*blood
MH  - China
MH  - Chromatography, High Pressure Liquid
MH  - Chronic Disease
MH  - Cytokines/*blood
MH  - Female
MH  - Heart Failure/*blood/physiopathology
MH  - Humans
MH  - Immunoradiometric Assay
MH  - Inflammation Mediators/*blood
MH  - Interleukin-10/blood
MH  - Interleukin-6/blood
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Predictive Value of Tests
MH  - Tumor Necrosis Factor-alpha/blood
EDAT- 2009/04/29 09:00
MHDA- 2009/06/12 09:00
CRDT- 2009/04/29 09:00
PHST- 2009/04/29 09:00 [entrez]
PHST- 2009/04/29 09:00 [pubmed]
PHST- 2009/06/12 09:00 [medline]
AID - 49/5/591 [pii]
AID - 10.1177/0091270009333265 [doi]
PST - ppublish
SO  - J Clin Pharmacol. 2009 May;49(5):591-9. doi: 10.1177/0091270009333265.