PMID- 19398927
OWN - NLM
STAT- MEDLINE
DCOM- 20100618
LR  - 20220330
IS  - 1539-2031 (Electronic)
IS  - 0192-0790 (Linking)
VI  - 43
IP  - 9
DP  - 2009 Oct
TI  - Comparison of reflux frequency during prolonged multichannel intraluminal 
      impedance and pH monitoring on and off acid suppression therapy.
PG  - 816-20
LID - 10.1097/MCG.0b013e318194592b [doi]
AB  - BACKGROUND: The aim of this study was to assess and compare reflux frequency 
      during prolonged multichannel intraluminal impedance and pH monitoring with 
      special attention to the 2-hour postprandial interval after the major meal in 
      patients on or off proton pump inhibitor (PPI) therapy. MATERIALS AND METHODS: We 
      retrospectively analyzed multichannel intraluminal impedance and pH studies 
      performed in 110 patients monitored on (n=70) or off PPI (n=40) to assess number 
      of acid and nonacid reflux episodes per hour (RE/h). RESULTS: Patients on PPI had 
      significantly higher mean number of nonacid than acid RE/h during the total 
      monitoring and 2-hour postprandially (pp). The mean number of nonacid RE/h was 
      significantly higher during 2-hour pp than the total monitoring period (4.5 vs. 
      1.7). Patients off PPI had significantly higher mean number of acid than nonacid 
      RE/h only during the total monitoring. The total number of RE/h was significantly 
      higher during 2-hour pp than the total monitoring (5.1 vs. 2.3). Patients on PPI 
      had significantly higher mean number of nonacid RE/h whereas patients off PPI had 
      significantly higher mean number of acid RE/h throughout total monitoring and 
      2-hour pp. Number of RE/h was numerically (2.3 vs. 1.7) but not statistically 
      greater off PPI than on PPI during total monitoring. CONCLUSIONS: The total 
      number of reflux episodes increases during the postprandial period irrespective 
      of PPI therapy. Maximal rate of reflux episodes occurs during the postprandial 
      period and is the same whether taking PPI or not.
FAU - Blonski, Wojciech
AU  - Blonski W
AD  - Division of Gastroenterology, Medical University of South Carolina, Charleston, 
      SC 29425, USA. blonskiw@musc.edu
FAU - Vela, Marcelo F
AU  - Vela MF
FAU - Castell, Donald O
AU  - Castell DO
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Clin Gastroenterol
JT  - Journal of clinical gastroenterology
JID - 7910017
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Electric Impedance
MH  - *Esophageal pH Monitoring
MH  - Esophagus/*metabolism/physiopathology
MH  - Female
MH  - Gastric Acid/*metabolism
MH  - Gastroesophageal Reflux/*diagnosis/*drug therapy/metabolism/physiopathology
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Male
MH  - Manometry
MH  - Middle Aged
MH  - Postprandial Period
MH  - Predictive Value of Tests
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Retrospective Studies
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2009/04/29 09:00
MHDA- 2010/06/19 06:00
CRDT- 2009/04/29 09:00
PHST- 2009/04/29 09:00 [entrez]
PHST- 2009/04/29 09:00 [pubmed]
PHST- 2010/06/19 06:00 [medline]
AID - 10.1097/MCG.0b013e318194592b [doi]
PST - ppublish
SO  - J Clin Gastroenterol. 2009 Oct;43(9):816-20. doi: 10.1097/MCG.0b013e318194592b.