PMID- 19399357
OWN - NLM
STAT- MEDLINE
DCOM- 20100330
LR  - 20211020
IS  - 1433-8491 (Electronic)
IS  - 0940-1334 (Linking)
VI  - 260
IP  - 1
DP  - 2010 Feb
TI  - Metabolic syndrome: a follow-up study of acute depressive inpatients.
PG  - 41-9
LID - 10.1007/s00406-009-0013-5 [doi]
AB  - Previous studies pointed out the high prevalence of the metabolic syndrome among 
      patients with bipolar disorder and major depression. A link between depression 
      and a metabolic syndrome remains in dispute despite these studies. This study was 
      conducted to evaluate the occurrence of the metabolic syndrome in depressive 
      inpatients, to analyze the association between the severity of depression and the 
      metabolic syndrome and to screen specific laboratory values in the course of 
      depressive illness. 60 acute depressive patients were recruited for the study and 
      underwent psychometric testing [21-item Hamilton Depression Rating Scale (HAMD), 
      Beck Depression Inventory (BDI), Clinical Global Impression Scale (CGI) and 
      Global Assessment of Functioning Scale (GAF)] and a metabolic syndrome screening 
      using the modified criteria of the American National Cholesterol Education 
      Program (NCEP) Treatment Panel III (ATP III). Moreover, CRP, cholesterol, 
      HDL-cholesterol, fasting glucose, triglyceride and leptin levels were measured. 
      42 patients were reexamined in state of (partial) remission. Depression was 
      reassessed using the 21-item HAMD, and laboratory values were analyzed a second 
      time. 25% of the depressive patients fulfilled the criteria of metabolic syndrome 
      (MS+). Only in the MS+ group, a positive correlation between triglyceride blood 
      levels and severity of depression became evident as well in the state of acute 
      depression as in the state of remission. In the group of patients without 
      metabolic syndrome, laboratory values were not associated with severity of 
      depression. An association between metabolic parameters and the course of 
      depression could only be detected in the group of patients with metabolic 
      syndrome. These findings suggest that, in these patients, a beneficial outcome of 
      depressive illness may improve the metabolic situation.
FAU - Richter, N
AU  - Richter N
AD  - Department of Psychiatry and Psychotherapy, LWL-Hospital Bochum, Ruhr University, 
      Alexandrinenstr. 1, 44791, Bochum, Germany.
FAU - Juckel, G
AU  - Juckel G
FAU - Assion, H-J
AU  - Assion HJ
LA  - eng
PT  - Journal Article
DEP - 20090428
PL  - Germany
TA  - Eur Arch Psychiatry Clin Neurosci
JT  - European archives of psychiatry and clinical neuroscience
JID - 9103030
RN  - 0 (Triglycerides)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Depression/*complications
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Metabolic Syndrome/blood/*complications
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Psychometrics
MH  - Retrospective Studies
MH  - Triglycerides/blood
MH  - Young Adult
EDAT- 2009/04/29 09:00
MHDA- 2010/03/31 06:00
CRDT- 2009/04/29 09:00
PHST- 2008/11/24 00:00 [received]
PHST- 2009/04/07 00:00 [accepted]
PHST- 2009/04/29 09:00 [entrez]
PHST- 2009/04/29 09:00 [pubmed]
PHST- 2010/03/31 06:00 [medline]
AID - 10.1007/s00406-009-0013-5 [doi]
PST - ppublish
SO  - Eur Arch Psychiatry Clin Neurosci. 2010 Feb;260(1):41-9. doi: 
      10.1007/s00406-009-0013-5. Epub 2009 Apr 28.