PMID- 19399644
OWN - NLM
STAT- MEDLINE
DCOM- 20100302
LR  - 20090624
IS  - 1559-0259 (Electronic)
IS  - 1530-7905 (Linking)
VI  - 9
IP  - 2
DP  - 2009 Jun
TI  - The cardiac effects of prolonged vitamin B12 and folate deficiency in rats.
PG  - 95-102
LID - 10.1007/s12012-009-9038-2 [doi]
AB  - In the recent past, hyperhomocysteinemia (HHCY) has been linked to chronic heart 
      failure. Folate and vitamin B12 deficiencies are the common causes of HHCY. The 
      impact of these vitamins on cardiac function and morphology has scarcely been 
      investigated. The aim of this study was to conduct an analysis of the cardiac 
      effect of folate and vitamin B12 deficiency in vivo. Two groups of rats, a 
      control (Co, n = 10) and a vitamin-deficient group (VitDef, n = 10), were fed for 
      12 weeks with a folate and vitamin B12-free diet or an equicaloric control diet. 
      Plasma and tissue concentrations of HCY, S-adenosyl-homocysteine (SAH), 
      S-adenosyl-methionine (SAM), and brain natriuretic peptide (BNP) were measured. 
      Moreover, echocardiographic and histomorphometric analyses were performed. VitDef 
      animals developed a significant HHCY (Co vs VitDef: 6.8 +/- 2.7 vs 61.1 +/- 12.8 
      micromol/l, P < 0.001). Fractional shortening, left ventricular dimension at 
      end-diastole and end-systole, posterior wall thickness, perivascular collagen, 
      mast cell number, and BNP tissue levels were comparable in VitDef and Co animals. 
      Interstitial collagen (Co vs VitDef: 6.8 +/- 3.0 vs 4.5 +/- 2.1%, P < 0.05), 
      plasma BNP (Co vs VitDef: 180 +/- 80 vs 70 +/- 60 ng/l, P < 0.05), and tissue HCY 
      (Co vs VitDef: 0.13 +/- 0.07 vs 0.07 +/- 0.04 micromol/g protein, P < 0.05) were 
      lower in VitDef animals. Folate and vitamin B12 deficiency do not affect cardiac 
      function and morphology.
FAU - Taban-Shomal, Omid
AU  - Taban-Shomal O
AD  - Department of Clinical Chemistry and Laboratory Medicine, University Hospital of 
      Saarland, 66421 Homburg/Saar, Germany.
FAU - Kilter, Heiko
AU  - Kilter H
FAU - Wagner, Alexandra
AU  - Wagner A
FAU - Schorr, Heike
AU  - Schorr H
FAU - Umanskaya, Natalia
AU  - Umanskaya N
FAU - Hubner, Ulrich
AU  - Hubner U
FAU - Bohm, Michael
AU  - Bohm M
FAU - Herrmann, Wolfgang
AU  - Herrmann W
FAU - Herrmann, Markus
AU  - Herrmann M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090428
PL  - United States
TA  - Cardiovasc Toxicol
JT  - Cardiovascular toxicology
JID - 101135818
SB  - IM
MH  - Animals
MH  - Cardiovascular Diseases/blood/etiology
MH  - Female
MH  - Folic Acid Deficiency/*blood/complications
MH  - Myocardium/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Time Factors
MH  - Vitamin B 12 Deficiency/*blood/complications
EDAT- 2009/04/29 09:00
MHDA- 2010/03/03 06:00
CRDT- 2009/04/29 09:00
PHST- 2009/03/02 00:00 [received]
PHST- 2009/04/07 00:00 [accepted]
PHST- 2009/04/29 09:00 [entrez]
PHST- 2009/04/29 09:00 [pubmed]
PHST- 2010/03/03 06:00 [medline]
AID - 10.1007/s12012-009-9038-2 [doi]
PST - ppublish
SO  - Cardiovasc Toxicol. 2009 Jun;9(2):95-102. doi: 10.1007/s12012-009-9038-2. Epub 
      2009 Apr 28.