PMID- 19401363
OWN - NLM
STAT- MEDLINE
DCOM- 20090806
LR  - 20220331
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 94
IP  - 7
DP  - 2009 Jul
TI  - Association between serum insulin-like growth factor (IGF) I and IGF binding 
      protein-3 and lung function.
PG  - 2452-8
LID - 10.1210/jc.2008-2662 [doi]
AB  - BACKGROUND: There is strong evidence that IGF-I and IGF binding protein 3 
      (IGFBP-3), as central mediators of endocrine and finally metabolic or anabolic 
      effects of GH, were associated with increased lung size in acromegaly or a 
      decrease of respiratory muscle pressures in patients with GH deficiency. The aim 
      of the present study was to further clarify the impact of IGF-I and IGFBP-3 
      levels on lung volumes and respiratory pressures in a general adult population. 
      MATERIAL AND METHODS: From the Study of Health in Pomerania, 1326 subjects aged 
      25 to 85 yr participated in standardized pulmonary function testing. IGF-I and 
      IGFBP-3 levels were measured with the Immulite 2500 system. Multivariable linear 
      regression analyses adjusted for age, sex, body mass index, physical activity, 
      and smoking were performed. RESULTS: In men, positive linear associations between 
      IGF-I and IGF-I/IGFBP-3 ratio with forced expiratory volume in 1 sec (FEV1) as 
      well as with forced vital capacity (FVC) were detected across all ages, whereas 
      in women this positive association was only detectable above 50 yr. Furthermore, 
      the analyses indicated positive linear relations of IGF-I/IGFBP-3 ratio with FEV1 
      and FVC, respectively. No significant relations between IGF-I or IGFBP-3 and 
      maximal inspiratory pressure was detectable in both sexes. CONCLUSION: In 
      conclusion, higher IGF-I levels were associated with higher lung volumes in men, 
      whereas in women this association was only detectable in subjects older than 50 
      yr. Higher IGF-I values were not associated with increased respiratory muscle 
      strength measured as maximal inspiratory pressure.
FAU - Glaser, Sven
AU  - Glaser S
AD  - Department of Internal Medicine B, Pulmonary Medicine and Infectious Diseases, 
      Ernst-Moritz-Arndt University Greifswald, D-17475 Greifswald, Germany. 
      glaeser.sven@gmail.com
FAU - Friedrich, Nele
AU  - Friedrich N
FAU - Ewert, Ralf
AU  - Ewert R
FAU - Schaper, Christoph
AU  - Schaper C
FAU - Nauck, Matthias
AU  - Nauck M
FAU - Dorr, Marcus
AU  - Dorr M
FAU - Volzke, Henry
AU  - Volzke H
FAU - Felix, Stephan B
AU  - Felix SB
FAU - Krebs, Alexander
AU  - Krebs A
FAU - Wallaschofski, Henri
AU  - Wallaschofski H
FAU - Koch, Beate
AU  - Koch B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090428
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Growth Disorders/blood/physiopathology
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 3/analysis/*blood
MH  - Insulin-Like Growth Factor I/*analysis
MH  - Lung/*physiology
MH  - Male
MH  - Middle Aged
MH  - Respiratory Function Tests
MH  - Sex Characteristics
EDAT- 2009/04/30 09:00
MHDA- 2009/08/07 09:00
CRDT- 2009/04/30 09:00
PHST- 2009/04/30 09:00 [entrez]
PHST- 2009/04/30 09:00 [pubmed]
PHST- 2009/08/07 09:00 [medline]
AID - jc.2008-2662 [pii]
AID - 10.1210/jc.2008-2662 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2009 Jul;94(7):2452-8. doi: 10.1210/jc.2008-2662. Epub 
      2009 Apr 28.