PMID- 19401628
OWN - NLM
STAT- MEDLINE
DCOM- 20090609
LR  - 20221207
IS  - 1423-0100 (Electronic)
IS  - 0300-5526 (Print)
IS  - 0300-5526 (Linking)
VI  - 52
IP  - 1
DP  - 2009
TI  - Host genetics, steatosis and insulin resistance among African Americans and 
      Caucasian Americans with hepatitis C virus genotype-1 infection.
PG  - 49-56
LID - 10.1159/000214380 [doi]
AB  - Hepatic steatosis is the accumulation of fat in liver cells. Insulin resistance 
      (IR) occurs when normal amounts of insulin do not stimulate insulin activity in 
      cells. Both conditions have been described in hepatitis C virus (HCV) infection 
      and are thought to be biologically related. This study examined the association 
      of genetic variants with steatosis and IR among 167 African Americans and 184 
      Caucasian Americans with HCV genotype-1. Steatosis was defined as at least 5% of 
      fat in cells on liver biopsy. IR was quantified as a score greater than 2 from 
      the Homeostasis Model Assessment, version 2.2 (HOMA2-IR). Associations were 
      investigated by estimating odds ratios separately by race. Statistically 
      significant associations (p < 0.05) were observed for variants in interleukin-10 
      (IL10), leptin receptor (LEPR), interleukin-6 (IL6) and transforming growth 
      factor beta-1 (TGF-beta1) for both outcomes. Some significant interactions were 
      observed between IL10,LEPR and TGF-beta1 polymorphisms and HOMA2-IR scores when 
      examining steatosis. The interaction of HOMA2-IR and IL10 was consistent in both 
      races whereas for LEPR and TGF-beta1 the interactions were statistically 
      significant in only one of the racial groups.These results could imply that some 
      IL10,LEPR and TGF-beta1 polymorphisms may modify an association between steatosis 
      and IR.
CI  - Copyright 2009 S. Karger AG, Basel.
FAU - Iuliano, A Danielle
AU  - Iuliano AD
AD  - Department of Epidemiology, Graduate School of Public Health, University of 
      Pittsburgh, Pittsburgh, Pa., USA.
FAU - Feingold, Eleanor
AU  - Feingold E
FAU - Wahed, Abdus S
AU  - Wahed AS
FAU - Kleiner, David E
AU  - Kleiner DE
FAU - Belle, Steven H
AU  - Belle SH
FAU - Conjeevaram, Hari S
AU  - Conjeevaram HS
FAU - Zmuda, Joseph
AU  - Zmuda J
FAU - Liang, T Jake
AU  - Liang TJ
FAU - Yee, Leland J
AU  - Yee LJ
CN  - Virahep-C Study
LA  - eng
GR  - U01 DK60329/DK/NIDDK NIH HHS/United States
GR  - M01 RR000079/RR/NCRR NIH HHS/United States
GR  - U01 DK60344/DK/NIDDK NIH HHS/United States
GR  - U01 DK60342/DK/NIDDK NIH HHS/United States
GR  - U01 DK60309/DK/NIDDK NIH HHS/United States
GR  - Z01 DK054511-01/ImNIH/Intramural NIH HHS/United States
GR  - Z01 DK054511-02/ImNIH/Intramural NIH HHS/United States
GR  - U01 DK060327/DK/NIDDK NIH HHS/United States
GR  - U01 DK060329-01/DK/NIDDK NIH HHS/United States
GR  - U01 DK60324/DK/NIDDK NIH HHS/United States
GR  - M01 RR016500/RR/NCRR NIH HHS/United States
GR  - U01 DK060340/DK/NIDDK NIH HHS/United States
GR  - U01 DK60345/DK/NIDDK NIH HHS/United States
GR  - U01 DK060345/DK/NIDDK NIH HHS/United States
GR  - M01 RR000645/RR/NCRR NIH HHS/United States
GR  - M01 RR000046/RR/NCRR NIH HHS/United States
GR  - U01 DK60349/DK/NIDDK NIH HHS/United States
GR  - KL2 RR024154/RR/NCRR NIH HHS/United States
GR  - U01 DK060349/DK/NIDDK NIH HHS/United States
GR  - U01 DK60327/DK/NIDDK NIH HHS/United States
GR  - U01 DK60352/DK/NIDDK NIH HHS/United States
GR  - U01 DK60341/DK/NIDDK NIH HHS/United States
GR  - U01 DK060342/DK/NIDDK NIH HHS/United States
GR  - U01 DK060341/DK/NIDDK NIH HHS/United States
GR  - U01 DK060352/DK/NIDDK NIH HHS/United States
GR  - U01 DK060335/DK/NIDDK NIH HHS/United States
GR  - U01 DK60335/DK/NIDDK NIH HHS/United States
GR  - U01 DK60346/DK/NIDDK NIH HHS/United States
GR  - U01 DK060324/DK/NIDDK NIH HHS/United States
GR  - U01 DK060309/DK/NIDDK NIH HHS/United States
GR  - ZIA DK054511-03/ImNIH/Intramural NIH HHS/United States
GR  - M01 RR000042/RR/NCRR NIH HHS/United States
GR  - U01 DK060344/DK/NIDDK NIH HHS/United States
GR  - U01 DK060346/DK/NIDDK NIH HHS/United States
GR  - Z99 DK999999/ImNIH/Intramural NIH HHS/United States
GR  - 1KL2 RR024154-01/RR/NCRR NIH HHS/United States
GR  - U01 DK60340/DK/NIDDK NIH HHS/United States
GR  - U01 DK060329/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
DEP - 20090425
PL  - Switzerland
TA  - Intervirology
JT  - Intervirology
JID - 0364265
RN  - 0 (Interleukins)
RN  - 0 (Receptors, Leptin)
RN  - 0 (Transforming Growth Factor beta1)
SB  - IM
MH  - Adult
MH  - *Black or African American
MH  - Fatty Liver/etiology/*genetics
MH  - Female
MH  - Genetic Variation
MH  - Genotype
MH  - Hepacivirus/*genetics
MH  - Hepatitis C, Chronic/*complications/genetics/physiopathology
MH  - Humans
MH  - Insulin Resistance/*genetics
MH  - Interleukins/genetics
MH  - Male
MH  - Middle Aged
MH  - Receptors, Leptin/genetics
MH  - Transforming Growth Factor beta1/genetics
MH  - United States
MH  - *White People
PMC - PMC2803674
MID - NIHMS164712
FIR - Afdhal, Nezam
IR  - Afdhal N
FIR - Geahigan, Tiffany
IR  - Geahigan T
FIR - Brown, Robert S Jr
IR  - Brown RS Jr
FIR - Dove, Lorna
IR  - Dove L
FIR - Stovel, Shana
IR  - Stovel S
FIR - Terrault, Norah
IR  - Terrault N
FIR - Straley, Stephanie
IR  - Straley S
FIR - Agudelo, Eliana
IR  - Agudelo E
FIR - Hinds, Melissa
IR  - Hinds M
FIR - Wiley, Thelma E
IR  - Wiley TE
FIR - Williams, Monique
IR  - Williams M
FIR - Howell, Charles D
IR  - Howell CD
FIR - Callison, Karen
IR  - Callison K
FIR - Jeffers, Lennox J
IR  - Jeffers LJ
FIR - McPherson Baker, Shvawn
IR  - McPherson Baker S
FIR - DeMedina, Maria
IR  - DeMedina M
FIR - Hermitt, Carol
IR  - Hermitt C
FIR - Conjeevaram, Hari S
IR  - Conjeevaram HS
FIR - Fontana, Robert J
IR  - Fontana RJ
FIR - Harsh, Donna
IR  - Harsh D
FIR - Fried, Michael W
IR  - Fried MW
FIR - Smith, Scott R
IR  - Smith SR
FIR - Theodore, Dickens
IR  - Theodore D
FIR - Zacks, Steven
IR  - Zacks S
FIR - Shrestha, Roshan
IR  - Shrestha R
FIR - Dougherty, Karen
IR  - Dougherty K
FIR - Davis, Paris
IR  - Davis P
FIR - Brown, Shirley
IR  - Brown S
FIR - Tavis, John E
IR  - Tavis JE
FIR - Di Bisceglie, Adrian
IR  - Di Bisceglie A
FIR - Yao, Ermei
IR  - Yao E
FIR - Donlin, Maureen
IR  - Donlin M
FIR - Cannon, Nathan
IR  - Cannon N
FIR - Wang, Ping
IR  - Wang P
FIR - Yang, Huiying
IR  - Yang H
FIR - Tang, George
IR  - Tang G
FIR - Wang, Dai
IR  - Wang D
FIR - Rosen, Hugo R
IR  - Rosen HR
FIR - Burton, James R
IR  - Burton JR
FIR - Klarquist, Jared
IR  - Klarquist J
FIR - Weston, Scott
IR  - Weston S
FIR - Taylor, Milton W
IR  - Taylor MW
FIR - Sanda, Corneliu
IR  - Sanda C
FIR - Schaley, Joel
IR  - Schaley J
FIR - Ferris, Mary
IR  - Ferris M
FIR - Belle, Steven H
IR  - Belle SH
FIR - Bilonick, Richard A
IR  - Bilonick RA
FIR - Block, Geoffrey
IR  - Block G
FIR - Cline, Jennifer
IR  - Cline J
FIR - Haritos, Marika
IR  - Haritos M
FIR - Im, KyungAh
IR  - Im K
FIR - Kelley, Stephanie
IR  - Kelley S
FIR - Kelsey, Sherry
IR  - Kelsey S
FIR - Koozer, Laurie
IR  - Koozer L
FIR - Lawlor, Sharon
IR  - Lawlor S
FIR - Thomas, Stephen B
IR  - Thomas SB
FIR - Wahed, Abdus
IR  - Wahed A
FIR - Wei, Yuling
IR  - Wei Y
FIR - Yee, Leland J
IR  - Yee LJ
FIR - Robuck, Patricia
IR  - Robuck P
FIR - Everhart, James
IR  - Everhart J
FIR - Hoofnagle, Jay H
IR  - Hoofnagle JH
FIR - Doo, Edward
IR  - Doo E
FIR - Liang, T Jake
IR  - Liang TJ
FIR - Seeff, Leonard B
IR  - Seeff LB
FIR - Kleiner, David E
IR  - Kleiner DE
EDAT- 2009/04/30 09:00
MHDA- 2009/06/10 09:00
PMCR- 2010/01/08
CRDT- 2009/04/30 09:00
PHST- 2008/08/26 00:00 [received]
PHST- 2009/02/11 00:00 [accepted]
PHST- 2009/04/30 09:00 [entrez]
PHST- 2009/04/30 09:00 [pubmed]
PHST- 2009/06/10 09:00 [medline]
PHST- 2010/01/08 00:00 [pmc-release]
AID - 000214380 [pii]
AID - 10.1159/000214380 [doi]
PST - ppublish
SO  - Intervirology. 2009;52(1):49-56. doi: 10.1159/000214380. Epub 2009 Apr 25.