PMID- 19403460
OWN - NLM
STAT- MEDLINE
DCOM- 20090514
LR  - 20240322
IS  - 1479-7364 (Electronic)
IS  - 1473-9542 (Print)
IS  - 1473-9542 (Linking)
VI  - 3
IP  - 3
DP  - 2009 Apr
TI  - Pharmacogenetics of antidepressant response: an update.
PG  - 257-74
AB  - The past few decades have witnessed much progress in the field of 
      pharmacogenetics. The identification of the genetic background that regulates the 
      antidepressant response has benefited from these advances. This review focuses on 
      the pharmacogenetics of the antidepressant response through the analysis and 
      discussion of the most compelling evidence in this line of research. Online 
      databases (Medline and PsycINFO) have been searched and the most replicated 
      association findings relating to the genetics of the antidepressant response have 
      been reported and discussed. Some replicated findings in the literature have 
      suggested the serotonin transporter promoter (5-HTTLPR), serotonin receptor 1A 
      (HTR1A), serotonin receptor 2A (HTR2A), brain derived neurotrophic factor (BDNF), 
      corticotropin releasing hormone receptor 1 (CRHR1) and FK506 binding protein 5 
      (FKBP5) as putative regulators of the antidepressant response. A high rate of 
      failure of replication has also been reported. Pharmacogenetics will hopefully 
      provide the basis for personalised antidepressant treatment that is able to 
      maximise the probability of a good response and to minimise side effects; 
      however, this goal is not achievable at the moment. The extent of the validity of 
      the replicated findings and the reasons for the poor results obtained from 
      studies of the pharmacogenetics of the antidepressant response are discussed.
FAU - Drago, Antonio
AU  - Drago A
AD  - Institute of Psychiatry, University of Bologna, Bologna, Bologna, Italy.
FAU - De Ronchi, Diana
AU  - De Ronchi D
FAU - Serretti, Alessandro
AU  - Serretti A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Hum Genomics
JT  - Human genomics
JID - 101202210
RN  - 0 (Antidepressive Agents)
SB  - IM
MH  - Antidepressive Agents/*therapeutic use
MH  - Depression/*drug therapy
MH  - Humans
MH  - *Pharmacogenetics
MH  - United States
PMC - PMC3500192
EDAT- 2009/05/01 09:00
MHDA- 2009/05/15 09:00
PMCR- 2009/04/01
CRDT- 2009/05/01 09:00
PHST- 2009/05/01 09:00 [entrez]
PHST- 2009/05/01 09:00 [pubmed]
PHST- 2009/05/15 09:00 [medline]
PHST- 2009/04/01 00:00 [pmc-release]
AID - E35450824X243084 [pii]
AID - 1479-7364-3-3-257 [pii]
AID - 10.1186/1479-7364-3-3-257 [doi]
PST - ppublish
SO  - Hum Genomics. 2009 Apr;3(3):257-74. doi: 10.1186/1479-7364-3-3-257.