PMID- 19404400
OWN - NLM
STAT- MEDLINE
DCOM- 20090807
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 4
IP  - 4
DP  - 2009
TI  - Complex evolution of a Y-chromosomal double homeobox 4 (DUX4)-related gene family 
      in hominoids.
PG  - e5288
LID - 10.1371/journal.pone.0005288 [doi]
LID - e5288
AB  - The human Y chromosome carries four human Y-chromosomal 
      euchromatin/heterochromatin transition regions, all of which are characterized by 
      the presence of interchromosomal segmental duplications. The Yq11.1/Yq11.21 
      transition region harbours a peculiar segment composed of an imperfectly 
      organized tandem-repeat structure encoding four members of the double homeobox 
      (DUX) gene family. By comparative fluorescence in situ hybridization (FISH) 
      analysis we have documented the primary appearance of Y-chromosomal DUX genes 
      (DUXY) on the gibbon Y chromosome. The major amplification and dispersal of DUXY 
      paralogs occurred after the gibbon and hominid lineages had diverged. Orthologous 
      DUXY loci of human and chimpanzee show a highly similar structural organization. 
      Sequence alignment survey, phylogenetic reconstruction and recombination 
      detection analyses of human and chimpanzee DUXY genes revealed the existence of 
      all copies in a common ancestor. Comparative analysis of the circumjacent 
      beta-satellites indicated that DUXY genes and beta-satellites evolved in concert. 
      However, evolutionary forces acting on DUXY genes may have induced amino acid 
      sequence differences in the orthologous chimpanzee and human DUXY open reading 
      frames (ORFs). The acquisition of complete ORFs in human copies might relate to 
      evolutionary advantageous functions indicating neo-functionalization. We propose 
      an evolutionary scenario in which an ancestral tandem array DUX gene cassette 
      transposed to the hominoid Y chromosome followed by lineage-specific chromosomal 
      rearrangements paved the way for a species-specific evolution of the 
      Y-chromosomal members of a large highly diverged homeobox gene family.
FAU - Schmidt, Julia
AU  - Schmidt J
AD  - Institute of Human Genetics, University of Freiburg, Freiburg, Germany.
FAU - Kirsch, Stefan
AU  - Kirsch S
FAU - Rappold, Gudrun A
AU  - Rappold GA
FAU - Schempp, Werner
AU  - Schempp W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090430
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (DUX4L1 protein, human)
RN  - 0 (Homeodomain Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Chromosomes, Human, Y
MH  - *Evolution, Molecular
MH  - Gene Rearrangement
MH  - Homeodomain Proteins/*genetics
MH  - Hominidae
MH  - Humans
MH  - Hylobates
MH  - In Situ Hybridization, Fluorescence
MH  - Multigene Family
MH  - Open Reading Frames
MH  - Pan troglodytes
MH  - *Phylogeny
MH  - *Y Chromosome
PMC - PMC2671837
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2009/05/01 09:00
MHDA- 2009/08/08 09:00
PMCR- 2009/04/30
CRDT- 2009/05/01 09:00
PHST- 2009/02/26 00:00 [received]
PHST- 2009/03/24 00:00 [accepted]
PHST- 2009/05/01 09:00 [entrez]
PHST- 2009/05/01 09:00 [pubmed]
PHST- 2009/08/08 09:00 [medline]
PHST- 2009/04/30 00:00 [pmc-release]
AID - 09-PONE-RA-08915 [pii]
AID - 10.1371/journal.pone.0005288 [doi]
PST - ppublish
SO  - PLoS One. 2009;4(4):e5288. doi: 10.1371/journal.pone.0005288. Epub 2009 Apr 30.