PMID- 19404568
OWN - NLM
STAT- MEDLINE
DCOM- 20110415
LR  - 20121226
IS  - 1432-5233 (Electronic)
IS  - 0940-5429 (Linking)
VI  - 47 Suppl 1
DP  - 2010 Dec
TI  - Analysis of the membrane fluidity of erythrocyte ghosts in diabetic, 
      spontaneously hypertensive rats.
PG  - 47-55
LID - 10.1007/s00592-009-0120-9 [doi]
AB  - Diabetes and hypertension are closely related diseases associated with changes in 
      membrane fluidity. Here, we measured the membrane fluidity of erythrocyte ghosts 
      from spontaneously hypertensive rats (SHR), with or without streptozotocin 
      (STZ)-induced diabetes, at the ages of 1, 3 and 6 months, by introducing the use 
      of the intramolecular excimer forming dipyrenylpropane (DPyP) in this model. Type 
      2 diabetes mellitus (T2DM) was induced in 48-h-old, newborn male SHR by 
      intraperitoneal injection of STZ. We found lower excimer to monomer (I (e)/I (m)) 
      DPyP ratios in diabetic SHR than in control SHR at 3 and 6 months old, indicating 
      a decrease in membrane fluidity. Simultaneously, the composition of fatty acids 
      was determined and it was found that the unsaturated to saturated fatty acids 
      ratio (U/S) was compatible with changes in membrane fluidity. These results 
      suggest that the change in fatty acid composition of erythrocyte ghosts 
      contributes significantly to the decreased membrane fluidity detected with DPyP 
      in diabetic SHR.
FAU - Perez-Hernandez, Ismael H
AU  - Perez-Hernandez IH
AD  - Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad 
      Nacional Autonoma de Mexico, Av de los Barrios No 1 Los Reyes Iztacala, CP 54090 
      Tlalnepantla, Estado de Mexico, Mexico.
FAU - Avendano-Flores, Yesica S
AU  - Avendano-Flores YS
FAU - Mejia-Zepeda, Ricardo
AU  - Mejia-Zepeda R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090429
PL  - Germany
TA  - Acta Diabetol
JT  - Acta diabetologica
JID - 9200299
RN  - 0 (Fatty Acids)
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Type 2/metabolism/*physiopathology
MH  - Disease Models, Animal
MH  - Erythrocyte Membrane/*physiology
MH  - Fatty Acids/metabolism
MH  - Humans
MH  - Hypertension/metabolism/*physiopathology
MH  - Male
MH  - *Membrane Fluidity
MH  - Rats
MH  - Rats, Inbred SHR
EDAT- 2009/05/01 09:00
MHDA- 2011/04/19 06:00
CRDT- 2009/05/01 09:00
PHST- 2009/01/08 00:00 [received]
PHST- 2009/04/06 00:00 [accepted]
PHST- 2009/05/01 09:00 [entrez]
PHST- 2009/05/01 09:00 [pubmed]
PHST- 2011/04/19 06:00 [medline]
AID - 10.1007/s00592-009-0120-9 [doi]
PST - ppublish
SO  - Acta Diabetol. 2010 Dec;47 Suppl 1:47-55. doi: 10.1007/s00592-009-0120-9. Epub 
      2009 Apr 29.