PMID- 19406499
OWN - NLM
STAT- MEDLINE
DCOM- 20090916
LR  - 20100915
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 84
IP  - 3
DP  - 2009 Jun
TI  - Interaction between HNF4A polymorphisms and physical activity in relation to type 
      2 diabetes-related traits: results from the Quebec Family Study.
PG  - 211-8
LID - 10.1016/j.diabres.2009.03.012 [doi]
AB  - AIMS: To test for associations between type 2 diabetes mellitus (T2DM)-related 
      traits and polymorphisms (SNPs) in the hepatocyte nuclear factor 4-alpha gene 
      (HNF4A) in the Quebec Family Study cohort, and determine whether these 
      associations are modulated by physical activity (PA). METHODS: Two HNF4A SNPs 
      (rs1885088 G>A; rs745975 C>T), previously reported to be associated with T2DM, 
      were studied in 528 non-diabetic subjects who underwent a 75g oral glucose 
      tolerance test (OGTT). Glucose, insulin and C-peptide plasma levels, measured in 
      the fasting state and during the OGTT, were used in the analysis. The amount 
      (hours per week) of PA was assessed by questionnaire. RESULTS: The HNF4A 
      rs1885088 SNP was not independently associated with T2DM-related traits, whereas 
      the rs745975 was associated with fasting insulin, HOMA-IR and 2-h glucose levels 
      (p<0.05 for all). Genotype by PA interactions were found for glucose homeostasis 
      (p<0.0001) and insulin secretion (p<or=0.03). When subjects were stratified by PA 
      level (according to the median value), we found that high level of PA (>2h/week) 
      was associated with smaller glucose area under the curve (AUC) and 2-h glucose 
      levels in rs1885088 A/A homozygotes and with lower fasting C-peptide and insulin 
      AUC in rs745975 T/T homozygotes. CONCLUSION: These results indicate that the 
      associations of HNF4A rs1885088 with glucose tolerance and rs745975 with insulin 
      secretion are modulated by PA. Our finding therefore suggests that the effect of 
      HNF4A polymorphisms on the risk of T2DM is influenced by PA.
FAU - Ruchat, Stephanie-May
AU  - Ruchat SM
AD  - Department of Preventive Medicine, Laval University, Quebec, Canada.
FAU - Weisnagel, John S
AU  - Weisnagel JS
FAU - Rankinen, Tuomo
AU  - Rankinen T
FAU - Bouchard, Claude
AU  - Bouchard C
FAU - Vohl, Marie-Claude
AU  - Vohl MC
FAU - Perusse, Louis
AU  - Perusse L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090429
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Blood Glucose)
RN  - 0 (HNF4A protein, human)
RN  - 0 (Hepatocyte Nuclear Factor 4)
SB  - IM
EIN - Diabetes Res Clin Pract. 2010 Oct;90(1):126. Stephanie-May, Ruchat [corrected to 
      Ruchat, Stephanie-May]; John, Weisnagel S [corrected to Weisnagel, John S]; 
      Tuomo, Rankinen [corrected to Rankinen, Tuomo]; Claude, Bouchard [corrected to 
      Bouchard, Claude]; Marie-Claude, Vohl [corrected to Vohl, Marie-C
MH  - Blood Glucose/metabolism
MH  - Diabetes Mellitus, Type 2/*genetics/physiopathology
MH  - *Exercise
MH  - Glucose Tolerance Test
MH  - Hepatocyte Nuclear Factor 4/blood/*genetics
MH  - Humans
MH  - *Motor Activity
MH  - *Polymorphism, Genetic
MH  - *Polymorphism, Single Nucleotide
MH  - Quebec
EDAT- 2009/05/02 09:00
MHDA- 2009/09/17 06:00
CRDT- 2009/05/02 09:00
PHST- 2008/09/05 00:00 [received]
PHST- 2009/03/10 00:00 [revised]
PHST- 2009/03/17 00:00 [accepted]
PHST- 2009/05/02 09:00 [entrez]
PHST- 2009/05/02 09:00 [pubmed]
PHST- 2009/09/17 06:00 [medline]
AID - S0168-8227(09)00127-2 [pii]
AID - 10.1016/j.diabres.2009.03.012 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2009 Jun;84(3):211-8. doi: 
      10.1016/j.diabres.2009.03.012. Epub 2009 Apr 29.