PMID- 19406562
OWN - NLM
STAT- MEDLINE
DCOM- 20100513
LR  - 20191210
IS  - 1873-7560 (Electronic)
IS  - 0302-2838 (Linking)
VI  - 57
IP  - 1
DP  - 2010 Jan
TI  - Factors predicting health-related quality of life recovery in patients undergoing 
      surgical treatment for renal tumors: prospective evaluation using the RAND SF-36 
      Health Survey.
PG  - 112-20
LID - 10.1016/j.eururo.2009.04.023 [doi]
AB  - BACKGROUND: Most newly diagnosed kidney cancers present at localized stages. With 
      appropriate treatments, the cancer-specific survival rates of such patients are 
      extremely high, which makes patients' health-related quality of life (HRQoL) a 
      relevant issue. To date, most of the available studies on HRQoL have been biased 
      by the absence of baseline HRQoL assessments and by retrospective designs. 
      OBJECTIVE: To evaluate the baseline HRQoL of patients with kidney cancer, 
      comparative HRQoL during the first year after surgery, and the prognostic factors 
      predictive of HRQoL recovery. DESIGN, SETTING, AND PARTICIPANTS: We prospectively 
      collected the data of all patients undergoing surgery for kidney tumors at a 
      tertiary academic referral center from February 2006 to September 2007. 
      INTERVENTIONS: Patients underwent nephron-sparing surgery (NSS) or radical 
      nephrectomy (RN). MEASUREMENTS: Patients were invited to self-complete the 
      validated, Italian version of the RAND 36-Item Health Survey 1.0 (SF-36) before 
      surgery, 6 mo after surgery, and 12 mo after surgery. RESULTS AND LIMITATIONS: 
      Overall, 129 consecutive patients were evaluated. No significant differences were 
      found between the baseline scores of our patients and age- and sex-matched 
      normative data for the Italian general population. Comparing the baseline SF-36 
      scores to those at 6 mo and 12 mo, there was statistically significant worsening 
      in the physical domains and improvement in the emotional domains (all p<0.05). 
      About 50-80% of patients returned to baseline scores 6 mo and 12 mo after 
      surgery. Age, body mass index (BMI), educational level, occupational status, New 
      York Heart Association (NYHA) functional class, tumor mode of presentation, 
      pathologic stage, size, and histologic subtype were associated with 6-mo and 
      12-mo return to the baseline HRQoL scores. The main limitation of the study was 
      the lack of a disease-specific questionnaire. CONCLUSIONS: Most patients returned 
      to preoperative HRQoL within 12 mo after RN or NSS. Several patient features, 
      clinical variables, and pathologic tumor variables predict the return of HRQoL.
FAU - Novara, Giacomo
AU  - Novara G
AD  - Department of Oncological and Surgical Sciences, Urologic Clinic, University of 
      Padua, Padua, Italy.
FAU - Secco, Silvia
AU  - Secco S
FAU - Botteri, Maria
AU  - Botteri M
FAU - De Marco, Vincenzo
AU  - De Marco V
FAU - Artibani, Walter
AU  - Artibani W
FAU - Ficarra, Vincenzo
AU  - Ficarra V
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20090421
PL  - Switzerland
TA  - Eur Urol
JT  - European urology
JID - 7512719
SB  - IM
CIN - Eur Urol. 2010 Jan;57(1):120-1. PMID: 19406566
MH  - Aged
MH  - Chi-Square Distribution
MH  - Disease Progression
MH  - Disease-Free Survival
MH  - Emotions
MH  - Female
MH  - Health Surveys
MH  - Humans
MH  - Italy
MH  - Kidney Neoplasms/diagnosis/mortality/physiopathology/psychology/*surgery
MH  - Laparoscopy
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - *Nephrectomy/methods
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - *Quality of Life
MH  - Recovery of Function
MH  - *Surveys and Questionnaires
MH  - Time Factors
MH  - Treatment Outcome
MH  - Tumor Burden
EDAT- 2009/05/02 09:00
MHDA- 2010/05/14 06:00
CRDT- 2009/05/02 09:00
PHST- 2008/12/19 00:00 [received]
PHST- 2009/04/08 00:00 [accepted]
PHST- 2009/05/02 09:00 [entrez]
PHST- 2009/05/02 09:00 [pubmed]
PHST- 2010/05/14 06:00 [medline]
AID - S0302-2838(09)00410-2 [pii]
AID - 10.1016/j.eururo.2009.04.023 [doi]
PST - ppublish
SO  - Eur Urol. 2010 Jan;57(1):112-20. doi: 10.1016/j.eururo.2009.04.023. Epub 2009 Apr 
      21.