PMID- 19407507
OWN - NLM
STAT- MEDLINE
DCOM- 20090723
LR  - 20090501
IS  - 1423-0046 (Electronic)
IS  - 0301-0163 (Linking)
VI  - 71 Suppl 2
DP  - 2009 Apr
TI  - Genetic, molecular and clinical features of familial isolated pituitary adenomas.
PG  - 116-22
LID - 10.1159/000192448 [doi]
AB  - Pituitary adenomas occur in a familial setting in about 5% of all cases, and over 
      half of these are due to multiple endocrine neoplasia type 1 (MEN1) and Carney's 
      complex (CNC). Non-MEN1/CNC familial pituitary tumours of all tumour phenotypes, 
      known as familial isolated pituitary adenomas (FIPA), were first described in the 
      late 1990s. Clinical features of FIPA differ from those of sporadic pituitary 
      adenomas, as patients with FIPA have a younger age at diagnosis and larger 
      tumours. About 15% of patients with FIPA have mutations in the aryl hydrocarbon 
      receptor-interacting protein gene (AIP), which indicates that FIPA may have a 
      diverse genetic pathophysiology. This article describes the clinical features of 
      FIPA, the tumour pathologies found in this setting and the genetic/molecular data 
      that have recently been reported in FIPA.
CI  - Copyright 2009 S. Karger AG, Basel.
FAU - Daly, Adrian F
AU  - Daly AF
AD  - Department of Endocrinology, Centre Hospitalier Universitaire de Liege, 
      University of Liege, Liege, Belgium.
FAU - Tichomirowa, Maria A
AU  - Tichomirowa MA
FAU - Beckers, Albert
AU  - Beckers A
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20090429
PL  - Switzerland
TA  - Horm Res
JT  - Hormone research
JID - 0366126
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (aryl hydrocarbon receptor-interacting protein)
SB  - IM
MH  - Animals
MH  - *Genetic Diseases, Inborn/genetics/metabolism/pathology/physiopathology
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/genetics/metabolism
MH  - *Pituitary Neoplasms/genetics/metabolism/pathology/physiopathology
MH  - Proto-Oncogene Proteins/genetics/metabolism
RF  - 43
EDAT- 2009/05/07 09:00
MHDA- 2009/07/25 09:00
CRDT- 2009/05/02 09:00
PHST- 2009/05/02 09:00 [entrez]
PHST- 2009/05/07 09:00 [pubmed]
PHST- 2009/07/25 09:00 [medline]
AID - 000192448 [pii]
AID - 10.1159/000192448 [doi]
PST - ppublish
SO  - Horm Res. 2009 Apr;71 Suppl 2:116-22. doi: 10.1159/000192448. Epub 2009 Apr 29.