PMID- 19407808
OWN - NLM
STAT- MEDLINE
DCOM- 20100129
LR  - 20091027
IS  - 1930-7381 (Print)
IS  - 1930-7381 (Linking)
VI  - 17
IP  - 11
DP  - 2009 Nov
TI  - Fat and water 1H MRI to investigate effects of leptin in obese mice.
PG  - 2089-93
LID - 10.1038/oby.2009.133 [doi]
AB  - Leptin is known to be associated with regulation of body weight and fat content. 
      The effects of exogenous leptin on abdominal visceral (VS) and subcutaneous (SC) 
      fat volume and hepatic fat-to-water ratio in leptin-deficient obese mice were 
      investigated by (1)H magnetic resonance imaging (MRI). Chemical shift-selected 
      fat and water (1)H MRI of control and leptin-treated mice were obtained 1 day 
      before treatment and after 7 days of treatment (0.3 mg/kg/day). Hepatic 
      fat-to-water ratio and VS fat volume decreased significantly with treatment, 
      whereas SC fat volume did not change. Noninvasive measurement of fat and water 
      content in different body regions using MRI should prove useful for evaluating 
      new drugs for the treatment of obesity and other metabolic disorders.
FAU - James, Judy R
AU  - James JR
AD  - Department of Radiology, Indiana University, School of Medicine, Indianapolis, 
      Indiana, USA.
FAU - Hertel, JeAnne L
AU  - Hertel JL
FAU - Babsky, Andriy M
AU  - Babsky AM
FAU - Hekmatyar, S K
AU  - Hekmatyar SK
FAU - Heiman, Mark L
AU  - Heiman ML
FAU - Jackson, Charles V
AU  - Jackson CV
FAU - Bansal, Navin
AU  - Bansal N
LA  - eng
GR  - R01EB005964/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20090430
PL  - United States
TA  - Obesity (Silver Spring)
JT  - Obesity (Silver Spring, Md.)
JID - 101264860
RN  - 0 (Leptin)
SB  - IM
MH  - Adipose Tissue/*anatomy & histology/physiology
MH  - Animals
MH  - Body Water/*chemistry/physiology
MH  - Body Weight/physiology
MH  - Drug Evaluation, Preclinical/methods
MH  - Infusions, Subcutaneous
MH  - Intra-Abdominal Fat/anatomy & histology/chemistry
MH  - Leptin/administration & dosage/deficiency/*pharmacology
MH  - Liver/chemistry/physiology
MH  - Magnetic Resonance Imaging
MH  - Mice
MH  - Mice, Obese
MH  - Subcutaneous Fat, Abdominal/anatomy & histology/chemistry
EDAT- 2009/05/02 09:00
MHDA- 2010/01/30 06:00
CRDT- 2009/05/02 09:00
PHST- 2009/05/02 09:00 [entrez]
PHST- 2009/05/02 09:00 [pubmed]
PHST- 2010/01/30 06:00 [medline]
AID - oby2009133 [pii]
AID - 10.1038/oby.2009.133 [doi]
PST - ppublish
SO  - Obesity (Silver Spring). 2009 Nov;17(11):2089-93. doi: 10.1038/oby.2009.133. Epub 
      2009 Apr 30.