PMID- 19407850
OWN - NLM
STAT- MEDLINE
DCOM- 20091009
LR  - 20230210
IS  - 1530-0285 (Electronic)
IS  - 0893-3952 (Linking)
VI  - 22
IP  - 8
DP  - 2009 Aug
TI  - HLA-G polymorphisms in women with squamous intraepithelial lesions harboring 
      human papillomavirus.
PG  - 1075-82
LID - 10.1038/modpathol.2009.67 [doi]
AB  - Human papillomavirus (HPV) infection is etiologically associated with low- (LSIL) 
      and high-grade squamous intraepithelial lesions (HSIL) and with cervical cancer. 
      The progression or regression of the lesions may depend, among other factors, on 
      the host heritable immune response. Because human leukocyte antigen (HLA)-G 
      molecules are involved in the modulation of innate and adaptive immune responses, 
      and because no previous studies have evaluated HLA-G polymorphism in patients 
      with SIL, we conducted a study to assess the association between HLA-G 
      polymorphisms and cervical lesions harboring HPV infection. Cervico-vaginal 
      scrapings and blood samples were collected from 125 women with SIL (68 LSIL and 
      57 HSIL) and from 94 healthy women without HPV infection and cytological 
      abnormalities. HPV type and HLA-G polymorphisms in exons 2, 3 and 8 (14 bp 
      insertion/deletion) were evaluated by PCR methodology, and digested with 
      restriction endonucleases. The Genepop software and the EM and PHASE algorithms 
      were used for statistical analysis. A significant protective association was 
      observed between the presence of the G(*)0103 allele and SIL and between the 
      G0101/G0104 genotype and HSIL in the group of patients compared to control. The 
      presence of the G0104/+14 bp and G0104/-14 bp haplotypes conferred susceptibility 
      to SIL compared to control. In addition, patients possessing the G0104/+14 bp 
      haplotype and harboring HPV-16 and -18 co-infections were particularly associated 
      with HSIL. These findings suggest that HLA-G polymorphisms may be associated with 
      HPV infection and SIL, consequently representing a profile of predisposition to 
      cervical cancer.
FAU - Simoes, Renata T
AU  - Simoes RT
AD  - Department of Pathology, School of Medicine of Ribeirao Preto, University of Sao 
      Paulo, Sao Paulo, Brazil.
FAU - Goncalves, Maria Alice G
AU  - Goncalves MA
FAU - Castelli, Erick C
AU  - Castelli EC
FAU - Junior, Celso M
AU  - Junior CM
FAU - Bettini, Jussara S R
AU  - Bettini JS
FAU - Discorde, Magali L
AU  - Discorde ML
FAU - Duarte, Geraldo
AU  - Duarte G
FAU - Quintana, Silvana M
AU  - Quintana SM
FAU - Simoes, Aguinaldo L
AU  - Simoes AL
FAU - Moreau, Philippe
AU  - Moreau P
FAU - Carosella, Edgardo D
AU  - Carosella ED
FAU - Soares, Edson G
AU  - Soares EG
FAU - Donadi, Eduardo A
AU  - Donadi EA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090501
PL  - United States
TA  - Mod Pathol
JT  - Modern pathology : an official journal of the United States and Canadian Academy 
      of Pathology, Inc
JID - 8806605
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Middle Aged
MH  - Papillomavirus Infections/*genetics
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic
MH  - Uterine Cervical Neoplasms/*genetics/pathology/virology
MH  - Young Adult
MH  - Uterine Cervical Dysplasia/*genetics/pathology/virology
EDAT- 2009/05/02 09:00
MHDA- 2009/10/10 06:00
CRDT- 2009/05/02 09:00
PHST- 2009/05/02 09:00 [entrez]
PHST- 2009/05/02 09:00 [pubmed]
PHST- 2009/10/10 06:00 [medline]
AID - S0893-3952(22)02492-9 [pii]
AID - 10.1038/modpathol.2009.67 [doi]
PST - ppublish
SO  - Mod Pathol. 2009 Aug;22(8):1075-82. doi: 10.1038/modpathol.2009.67. Epub 2009 May 
      1.