PMID- 1940794
OWN - NLM
STAT- MEDLINE
DCOM- 19911213
LR  - 20190508
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 174
IP  - 5
DP  - 1991 Nov 1
TI  - T cell receptor V-segment frequencies in peripheral blood T cells correlate with 
      human leukocyte antigen type.
PG  - 1139-46
AB  - We compared T cell receptor (TCR) V-segment frequencies in human leukocyte 
      antigen (HLA) identical siblings to sibling pairs who differ at one or both HLA 
      haplotypes using four V beta-specific and one V alpha-specific monoclonal 
      antibody. In every one of nine families HLA-identical sibs had the most similar 
      patterns of V-segment frequencies in their peripheral blood, whereas totally 
      mismatched sibs were, in general, the most dissimilar; HLA haploidentical sibs 
      tended to be intermediate between the two groups. The degree of similarity among 
      HLA-identical sibs was comparable to that observed among three pairs of identical 
      twins suggesting that HLA is the major genetic component influencing TCR 
      V-segment frequency. Consistent with this observation, it was found that the 
      frequency of T cells expressing particular V beta segments was skewed towards 
      either CD4+ or CD8+ cells indicating that T cells expressing some V beta genes 
      may be positively selected primarily by class I or class II major 
      histocompatibility complex proteins. Finally, it was observed that individuals 
      who express the HLA class I specificity, B38, tend to express high levels of V 
      alpha 2.3+ cells among their CD8+ T cells. These observations represent 
      definitive proof that human V-segment frequencies are profoundly influenced by 
      the HLA complex.
FAU - Gulwani-Akolkar, B
AU  - Gulwani-Akolkar B
AD  - Department of Medicine, North Shore University Hospital, Manhasset, New York.
FAU - Posnett, D N
AU  - Posnett DN
FAU - Janson, C H
AU  - Janson CH
FAU - Grunewald, J
AU  - Grunewald J
FAU - Wigzell, H
AU  - Wigzell H
FAU - Akolkar, P
AU  - Akolkar P
FAU - Gregersen, P K
AU  - Gregersen PK
FAU - Silver, J
AU  - Silver J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, Antigen, T-Cell)
SB  - IM
MH  - Alleles
MH  - Antibodies, Monoclonal/immunology
MH  - CD4-CD8 Ratio
MH  - HLA Antigens/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Receptors, Antigen, T-Cell/*analysis
MH  - T-Lymphocytes/*immunology
PMC - PMC2118988
EDAT- 1991/11/01 00:00
MHDA- 1991/11/01 00:01
PMCR- 1992/05/01
CRDT- 1991/11/01 00:00
PHST- 1991/11/01 00:00 [pubmed]
PHST- 1991/11/01 00:01 [medline]
PHST- 1991/11/01 00:00 [entrez]
PHST- 1992/05/01 00:00 [pmc-release]
AID - 92044306 [pii]
AID - 10.1084/jem.174.5.1139 [doi]
PST - ppublish
SO  - J Exp Med. 1991 Nov 1;174(5):1139-46. doi: 10.1084/jem.174.5.1139.