PMID- 19408052
OWN - NLM
STAT- MEDLINE
DCOM- 20090819
LR  - 20151119
IS  - 1534-4681 (Electronic)
IS  - 1068-9265 (Linking)
VI  - 16
IP  - 7
DP  - 2009 Jul
TI  - Preoperative serum angiopoietin-2 levels correlate with lymph node status in 
      patients with early gastric cancer.
PG  - 2052-7
LID - 10.1245/s10434-009-0474-9 [doi]
AB  - BACKGROUND: Lymph node metastasis is the most important factor to consider when 
      deciding on the modality of resection in patients with early gastric cancer. The 
      aim of the present study was to assess the relationship between preoperative 
      serum angiopoietin-2, a lymphangiogenic growth factor, and lymph node metastasis 
      in patients with early gastric cancer. METHODS: A total of 62 preoperative serum 
      samples from patients diagnosed with early gastric adenocarcinoma, and 30 serum 
      samples from healthy donors were obtained. The serum levels of angiopoietin-2 
      (Ang-2) were quantified by immunoassay. Intra- and peritumor lymphatic vessel 
      density (I-LVD and P-LVD) were counted after immunohistochemical staining. The 
      relationship between the serum Ang-2 levels and other prognostic variables (tumor 
      size, histological type, depth of tumor invasion, I-LDV, P-LDV, presence of lymph 
      node involvement, and distant metastasis) were then examined by univariate and 
      multivariate linear regression analyses. RESULTS: The median serum levels of 
      Ang-2 in patients were higher than those of healthy controls [311.1 ng/mL, 
      interquartile range (IQR) 256.7-311.1 ng/mL versus 286.5 ng/mL, IQR 226.9-286.5 
      ng/mL; Mann-Whitney test, P = 0.016]. Eight patients had metastatic lymph nodes; 
      the Ang-2 levels from the patients with metastatic lymph nodes were higher than 
      from those with negative lymph nodes (297.5 ng/mL, IQR 251.1-385.8 ng/mL versus 
      416.0 ng/mL, IQR 337.1-485.5 ng/mL; Mann-Whitney test, P = 0.019). Elevated serum 
      Ang-2 levels were associated with positive lymph node involvement and this 
      finding was significant on univariate (P = 0.008) and multivariate logistic 
      regression analysis (P = 0.011). CONCLUSION: Serum Ang-2 levels were clinically 
      useful markers for lymph node metastasis in patients with early gastric cancer.
FAU - Jo, Min Jung
AU  - Jo MJ
AD  - Gastric Cancer Branch, National Cancer Center, Goyang-si, Gyeonggi-do, Korea.
FAU - Lee, Jun Ho
AU  - Lee JH
FAU - Nam, Byung-Ho
AU  - Nam BH
FAU - Kook, Myeong Cherl
AU  - Kook MC
FAU - Ryu, Keun Won
AU  - Ryu KW
FAU - Choi, Il Ju
AU  - Choi IJ
FAU - Kim, Young-Woo
AU  - Kim YW
FAU - Bae, Jae-Moon
AU  - Bae JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090430
PL  - United States
TA  - Ann Surg Oncol
JT  - Annals of surgical oncology
JID - 9420840
RN  - 0 (Angiopoietin-2)
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Adenocarcinoma/blood/*pathology/surgery
MH  - Aged
MH  - Angiopoietin-2/*blood
MH  - Biomarkers, Tumor/*blood
MH  - Female
MH  - Humans
MH  - Lymph Nodes/*pathology
MH  - Lymphatic Metastasis
MH  - Lymphatic Vessels/pathology
MH  - Male
MH  - Middle Aged
MH  - Stomach Neoplasms/blood/*pathology/surgery
EDAT- 2009/05/02 09:00
MHDA- 2009/08/20 09:00
CRDT- 2009/05/02 09:00
PHST- 2009/02/14 00:00 [received]
PHST- 2009/03/25 00:00 [accepted]
PHST- 2009/05/02 09:00 [entrez]
PHST- 2009/05/02 09:00 [pubmed]
PHST- 2009/08/20 09:00 [medline]
AID - 10.1245/s10434-009-0474-9 [doi]
PST - ppublish
SO  - Ann Surg Oncol. 2009 Jul;16(7):2052-7. doi: 10.1245/s10434-009-0474-9. Epub 2009 
      Apr 30.