PMID- 19408607
OWN - NLM
STAT- MEDLINE
DCOM- 20090519
LR  - 20131121
IS  - 0350-6134 (Print)
IS  - 0350-6134 (Linking)
VI  - 33
IP  - 1
DP  - 2009 Mar
TI  - Tissue ischemia due to CO2 pressure during laparoscopic radical prostatectomy.
PG  - 77-82
AB  - Laparoscopic radical prostatectomy is nowadays one of the most frequently 
      performed urological surgical procedures. For insufflation in laparoscopic 
      radical prostatectomy (LRP) CO2 is used, with the pressure in the operative 
      region between 12 and 15 mm Hg. At the microcirculation level, the pressure is 
      lower, which raises the possibility of ischemic tissue damage during the 
      procedure. The activity of glutathione peroxidase (GSH-px), superoxide dismutase 
      (SOD) and catalase (CAT) was measured at the beginning and immediately after the 
      end of the surgery in 44 patients who underwent LRP and in 11 who underwent 
      retropubic radical prostatectomy (RRP). Capillary endothelial damage was assessed 
      by applying immunohistochemical and morphometric methods to tissue samples from 
      the urinary bladder neck, which contains all layers of the bladder wall. 
      Measurement of the enzyme activity showed no significant increase of GSH-px 
      (p-0.431), SOD (p-0.220) and CAT (p-0.434) levels. Neither immunohistochemical 
      analysis of the bladder neck capillaries with i-nitric oxide synthase (i-NOS) nor 
      morphometric analysis showed signs of endothelial ischemic damage.
FAU - Vodopija, Nado
AU  - Vodopija N
AD  - Department of Urology, General Hospital, Slovenj Gradec, Slovenia.
FAU - Ovcak, Zdenka
AU  - Ovcak Z
FAU - Zupancic, Marko
AU  - Zupancic M
FAU - Korsic, Ljubo
AU  - Korsic L
FAU - Kramer, Franc
AU  - Kramer F
FAU - Krstanoski, Zoran
AU  - Krstanoski Z
FAU - Parac, Ivan
AU  - Parac I
LA  - eng
PT  - Journal Article
PL  - Croatia
TA  - Coll Antropol
JT  - Collegium antropologicum
JID - 8003354
RN  - 142M471B3J (Carbon Dioxide)
SB  - IM
MH  - Carbon Dioxide
MH  - Endothelium, Vascular/pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Ischemia/*etiology/pathology
MH  - Laparoscopy/*adverse effects
MH  - Male
MH  - Middle Aged
MH  - Oxidative Stress
MH  - Pressure
MH  - Prostatectomy/*adverse effects
EDAT- 2009/05/05 09:00
MHDA- 2009/05/20 09:00
CRDT- 2009/05/05 09:00
PHST- 2009/05/05 09:00 [entrez]
PHST- 2009/05/05 09:00 [pubmed]
PHST- 2009/05/20 09:00 [medline]
PST - ppublish
SO  - Coll Antropol. 2009 Mar;33(1):77-82.