PMID- 19409091
OWN - NLM
STAT- MEDLINE
DCOM- 20090603
LR  - 20211203
IS  - 1743-422X (Electronic)
IS  - 1743-422X (Linking)
VI  - 6
DP  - 2009 May 1
TI  - Ethnic and geographical differences in HLA associations with the outcome of 
      hepatitis C virus infection.
PG  - 46
LID - 10.1186/1743-422X-6-46 [doi]
AB  - BACKGROUND: The association of human leukocyte antigen (HLA) genes with the 
      outcome of hepatitis C virus (HCV) infection may be modified by ethnic and 
      geographical differences. RESULTS: HLA-A, -C, -DRB1 and -DQB1 genotyping were 
      performed in a Midwestern American cohort of 105 HCV infected subjects among 
      which 49 cleared HCV infection and 56 had persistent viral infection. A new 
      protective association of HLA-Cw*05 to HCV infection of all ethnic populations 
      was identified (OR = 0.12, 95% CI = 0.01-0.97, P = 0.03). It was surprising that 
      HLA-A*02 (P for interaction = 0.02) and HLA-DRB1*12 (P for interaction = 0.05) 
      showed statistical interaction with race indicating opposite associations in 
      Caucasians (OR = 2.74 for A*02 and 2.15 for DRB1*12) and non-Caucasians (OR = 
      0.41 for A*02 and 0.15 for DRB1*12). In addition, HLA-DRB1*01 (OR = 0.26), 
      DQB1*05 (OR = 0.23) and the haplotype DRB1*01-DQB1*05 (OR = 0.19) showed strong 
      associations with viral clearance in Caucasians. The protective associations of 
      A*03 (OR = 0.20) and DQB1*03 (OR = 0.20) were exclusive to non-Caucasians. In 
      contrast, DQB1*02 (OR = 2.56, 95% CI = 1.15-7.71, P = 0.02) and the haplotype 
      DRB1*07-DQB1*02 (OR = 5.25, 95% CI = 1.04-26.6, P = 0.03) were risk markers in 
      Caucasians. CONCLUSION: The associations of HLA-A*02 and HLA-DRB1*12 with HCV 
      infection are opposite with different races. HLA-A*03, Cw*05, DRB1*01, DQB1*03 
      and DQB1*05 are associated with viral clearance while HLA-DRB1*07 and DQB1*02 are 
      risk markers for viral persistence of HCV infection in Midwestern Americans. 
      These results reveal ethnically and geographically different distribution of 
      HLA-genes which are associated with the outcome of HCV infection.
FAU - Wang, Jane H
AU  - Wang JH
AD  - Division of Hepatology, Department of Medicine, University of Illinois at 
      Chicago, IL, USA. wjane60527@yahoo.com
FAU - Zheng, Xin
AU  - Zheng X
FAU - Ke, Xiaogang
AU  - Ke X
FAU - Dorak, M Tevfik
AU  - Dorak MT
FAU - Shen, Jingjing
AU  - Shen J
FAU - Boodram, Basmattee
AU  - Boodram B
FAU - O'Gorman, Maurice
AU  - O'Gorman M
FAU - Beaman, Kenneth
AU  - Beaman K
FAU - Cotler, Scott J
AU  - Cotler SJ
FAU - Hershow, Ronald
AU  - Hershow R
FAU - Rong, Lijun
AU  - Rong L
LA  - eng
GR  - K01 DK002970/DK/NIDDK NIH HHS/United States
GR  - R01 DA013765/DA/NIDA NIH HHS/United States
GR  - K01 DK02970/DK/NIDDK NIH HHS/United States
GR  - R03 AI048056/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090501
PL  - England
TA  - Virol J
JT  - Virology journal
JID - 101231645
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Female
MH  - Gene Frequency
MH  - Geography
MH  - HLA Antigens/*genetics
MH  - Hepacivirus/physiology
MH  - Hepatitis C/epidemiology/*ethnology/*genetics
MH  - Humans
MH  - Male
MH  - Midwestern United States/epidemiology/ethnology
MH  - Racial Groups/*ethnology/*genetics
MH  - Risk Factors
MH  - Young Adult
PMC - PMC2679741
EDAT- 2009/05/05 09:00
MHDA- 2009/06/06 09:00
PMCR- 2009/05/01
CRDT- 2009/05/05 09:00
PHST- 2009/04/13 00:00 [received]
PHST- 2009/05/01 00:00 [accepted]
PHST- 2009/05/05 09:00 [entrez]
PHST- 2009/05/05 09:00 [pubmed]
PHST- 2009/06/06 09:00 [medline]
PHST- 2009/05/01 00:00 [pmc-release]
AID - 1743-422X-6-46 [pii]
AID - 10.1186/1743-422X-6-46 [doi]
PST - epublish
SO  - Virol J. 2009 May 1;6:46. doi: 10.1186/1743-422X-6-46.