PMID- 19409109
OWN - NLM
STAT- MEDLINE
DCOM- 20090709
LR  - 20211020
IS  - 1471-2172 (Electronic)
IS  - 1471-2172 (Linking)
VI  - 10
DP  - 2009 May 4
TI  - Association of IL-10 and IL-10Rbeta gene polymorphisms with graft-versus-host 
      disease after haematopoietic stem cell transplantation from an HLA-identical 
      sibling donor.
PG  - 24
LID - 10.1186/1471-2172-10-24 [doi]
AB  - BACKGROUND: Extensive allelic matching in the human leukocyte antigen (HLA) genes 
      is regarded as a prerequisite for good clinical success of allogeneic 
      haematopoietic stem cell transplantation (HSCT). Also other genetic factors can 
      be assumed to play a role in preventing and controlling the complications 
      associated with allogeneic HSCT, in particular graft-versus-host disease (GvHD). 
      Interleukin-10 (IL-10) and its receptor (IL-10R), key regulators of the immune 
      response, are among these candidates. We studied the association of IL-10 and 
      IL-10Rbeta gene polymorphisms with the occurrence of GvHD in 309 HLA-identical 
      sibling donor and recipient pairs. RESULTS: The difference in genotypic IL-10 
      production between patient and donor in combination with patient IL-10Rbeta A/A 
      genotype predisposed strongly to acute GvHD (OR = 7.15, p = 0.000023). On the 
      other hand, a combination of same genotypic IL-10 production with patient 
      IL-10Rbeta A/A genotype protected from chronic GvHD (OR = 0.407, p = 0.0097). 
      CONCLUSION: Our results suggest that IL-10 and IL-10Rbeta genes have a 
      synergistic effect on the risk of GvHD.
FAU - Sivula, Jyrki
AU  - Sivula J
AD  - Research and Development, Finnish Red Cross Blood Service, Helsinki, Finland. 
      jyrki.sivula@helsinki.fi
FAU - Turpeinen, Hannu
AU  - Turpeinen H
FAU - Volin, Liisa
AU  - Volin L
FAU - Partanen, Jukka
AU  - Partanen J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090504
PL  - England
TA  - BMC Immunol
JT  - BMC immunology
JID - 100966980
RN  - 0 (HLA Antigens)
RN  - 0 (Interleukin-10 Receptor beta Subunit)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Chronic Disease
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Graft vs Host Disease/etiology/*genetics/immunology
MH  - HLA Antigens/genetics/immunology
MH  - Haplotypes
MH  - Hematologic Neoplasms/*therapy
MH  - Hematopoietic Stem Cell Transplantation/adverse effects
MH  - Histocompatibility Testing
MH  - Humans
MH  - Interleukin-10/*genetics/immunology
MH  - Interleukin-10 Receptor beta Subunit/*genetics/immunology
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Siblings
PMC - PMC2685414
EDAT- 2009/05/05 09:00
MHDA- 2009/07/10 09:00
PMCR- 2009/05/04
CRDT- 2009/05/05 09:00
PHST- 2008/06/23 00:00 [received]
PHST- 2009/05/04 00:00 [accepted]
PHST- 2009/05/05 09:00 [entrez]
PHST- 2009/05/05 09:00 [pubmed]
PHST- 2009/07/10 09:00 [medline]
PHST- 2009/05/04 00:00 [pmc-release]
AID - 1471-2172-10-24 [pii]
AID - 10.1186/1471-2172-10-24 [doi]
PST - epublish
SO  - BMC Immunol. 2009 May 4;10:24. doi: 10.1186/1471-2172-10-24.