PMID- 19409809
OWN - NLM
STAT- MEDLINE
DCOM- 20090921
LR  - 20221207
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Linking)
VI  - 47
IP  - 1
DP  - 2009 Jul
TI  - Urinary monocyte chemoattractant protein-1 (MCP-1) and connective tissue growth 
      factor (CCN2) as prognostic markers for progression of diabetic nephropathy.
PG  - 37-42
LID - 10.1016/j.cyto.2009.04.001 [doi]
AB  - Profibrotic growth factors and inflammatory chemokines have been implicated in 
      the pathogenesis of diabetic nephropathy (DN). However, measurement of urinary 
      monocyte chemoattractant protein-1 (MCP-1) and connective tissue growth factor 
      (CCN2) as prognostic markers has not previously been reported, and neither have 
      two such molecules in urine been examined in a single study of DN. In this 
      prospective observational study, 43 adult diabetic patients were studied, 40 were 
      followed up for 6years. Urinary MCP-1/creatinine ratios were found to be 
      significantly higher in patients with macroalbuminuria (3.3- and 2.1-fold higher 
      (p<0.01) than normoalbuminuric and microalbuminuric patients, respectively). CCN2 
      exhibited a pattern different from that of urinary MCP-1. Urinary CCN2/creatinine 
      ratios were greatly elevated in both microalbuminuric and macroalbuminuric 
      patients (125- and 74-fold higher than normoalbuminuric patients, respectively, 
      p<0.01 and p<0.05, respectively). Further, urinary CCN2, but not MCP-1, 
      correlated with progression of microalbuminuria (R=0.49, p<0.05). In contrast, 
      MCP-1, but not CCN2, correlated with the rate of eGFR decline for all patients 
      (R=0.61, p<0.0001), reflective of its predictive value in patients with 
      macroalbuminuria, but not for patients with microalbuminuria or normoalbuminuria. 
      In conclusion, increased urinary CCN2 is associated with the early progression of 
      DN, whereas MCP-1 is associated with later stage disease.
FAU - Tam, Frederick W K
AU  - Tam FW
AD  - Imperial College Kidney and Transplant Institute, Renal Section, Division of 
      Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 
      0NN, UK. f.tam@imperial.ac.uk
FAU - Riser, Bruce L
AU  - Riser BL
FAU - Meeran, Karim
AU  - Meeran K
FAU - Rambow, JoAnn
AU  - Rambow J
FAU - Pusey, Charles D
AU  - Pusey CD
FAU - Frankel, Andrew H
AU  - Frankel AH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090505
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (CCN2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 139568-91-5 (Connective Tissue Growth Factor)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Albuminuria/urine
MH  - Biomarkers/urine
MH  - Blood Pressure/physiology
MH  - Chemokine CCL2/*urine
MH  - Connective Tissue Growth Factor/*urine
MH  - Creatinine/urine
MH  - Diabetes Mellitus, Type 1/complications/urine
MH  - Diabetes Mellitus, Type 2/complications/urine
MH  - Diabetic Nephropathies/*diagnosis/physiopathology/*urine
MH  - Diabetic Retinopathy/urine
MH  - Female
MH  - Glomerular Filtration Rate/physiology
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Young Adult
EDAT- 2009/05/05 09:00
MHDA- 2009/09/22 06:00
CRDT- 2009/05/05 09:00
PHST- 2008/09/18 00:00 [received]
PHST- 2009/03/02 00:00 [revised]
PHST- 2009/04/01 00:00 [accepted]
PHST- 2009/05/05 09:00 [entrez]
PHST- 2009/05/05 09:00 [pubmed]
PHST- 2009/09/22 06:00 [medline]
AID - S1043-4666(09)00102-1 [pii]
AID - 10.1016/j.cyto.2009.04.001 [doi]
PST - ppublish
SO  - Cytokine. 2009 Jul;47(1):37-42. doi: 10.1016/j.cyto.2009.04.001. Epub 2009 May 5.