PMID- 19409951
OWN - NLM
STAT- MEDLINE
DCOM- 20100312
LR  - 20151119
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 33
IP  - 5
DP  - 2009 Aug 1
TI  - Brain-derived neurotrophic factor plasma levels in patients suffering from 
      post-traumatic stress disorder.
PG  - 899-902
LID - 10.1016/j.pnpbp.2009.04.018 [doi]
AB  - In both animals and humans, stress has been demonstrated to reduce the expression 
      of the Brain-Derived Neurotrophic Factor (BDNF), a neurotrophin (NT) which 
      promotes the proliferation, survival and differentiation of neurons. Although 
      traumatic events have been found to be associated with lower BDNF plasma levels 
      in affective disorders, no study has explored this parameter in patients with 
      post-traumatic stress disorder (PTSD). We, therefore, measured BDNF plasma level 
      in 18 patients with PTSD and in 18 healthy control subjects. Diagnoses were 
      assessed by the Structured Clinical Interview for DSM-IV, while the specific 
      symptoms were examined in the patients by means of the Impact of Event Scale for 
      PTSD and the traumas experienced were assessed by using the Life Events 
      Checklist. BDNF plasma levels were evaluated by means of a standardized Elisa 
      method. The results, while showing significantly lower BDNF levels in PTSD 
      patients, as compared with those of healthy subjects (p=0.001), although obtained 
      in a small sample size, would suggest that this NT may be involved in the 
      pathophysiology of PTSD.
FAU - Dell'Osso, Liliana
AU  - Dell'Osso L
AD  - Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, 
      University of Pisa, Via Roma 67, 56100 Pisa, Italy.
FAU - Carmassi, Claudia
AU  - Carmassi C
FAU - Del Debbio, Alessandro
AU  - Del Debbio A
FAU - Catena Dell'Osso, Mario
AU  - Catena Dell'Osso M
FAU - Bianchi, Carolina
AU  - Bianchi C
FAU - da Pozzo, Eleonora
AU  - da Pozzo E
FAU - Origlia, Nicola
AU  - Origlia N
FAU - Domenici, Luciano
AU  - Domenici L
FAU - Massimetti, Gabriele
AU  - Massimetti G
FAU - Marazziti, Donatella
AU  - Marazziti D
FAU - Piccinni, Armando
AU  - Piccinni A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20090503
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Female
MH  - Humans
MH  - Life Change Events
MH  - Male
MH  - Middle Aged
MH  - Stress Disorders, Post-Traumatic/*blood/diagnosis/psychology
EDAT- 2009/05/05 09:00
MHDA- 2010/03/13 06:00
CRDT- 2009/05/05 09:00
PHST- 2009/02/25 00:00 [received]
PHST- 2009/04/01 00:00 [revised]
PHST- 2009/04/20 00:00 [accepted]
PHST- 2009/05/05 09:00 [entrez]
PHST- 2009/05/05 09:00 [pubmed]
PHST- 2010/03/13 06:00 [medline]
AID - S0278-5846(09)00128-6 [pii]
AID - 10.1016/j.pnpbp.2009.04.018 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2009 Aug 1;33(5):899-902. doi: 
      10.1016/j.pnpbp.2009.04.018. Epub 2009 May 3.