PMID- 19410506
OWN - NLM
STAT- MEDLINE
DCOM- 20090612
LR  - 20090601
IS  - 1872-8952 (Electronic)
IS  - 1388-2457 (Linking)
VI  - 120
IP  - 6
DP  - 2009 Jun
TI  - Towards neurophysiological assessment of phonemic discrimination: context effects 
      of the mismatch negativity.
PG  - 1078-86
LID - 10.1016/j.clinph.2009.01.018 [doi]
AB  - OBJECTIVE: This study focusses on the optimal paradigm for simultaneous 
      assessment of auditory and phonemic discrimination in clinical populations. We 
      investigated (a) whether pitch and phonemic deviants presented together in one 
      sequence are able to elicit mismatch negativities (MMNs) in healthy adults and 
      (b) whether MMN elicited by a change in pitch is modulated by the presence of the 
      phonemic deviants. METHODS: Standard stimuli [i] were intermixed with small, 
      medium or large pitch deviants or with pitch deviants of the same magnitude 
      together with small and large phonemic deviants, [y] and [u], respectively. 
      RESULTS: When pitch and phonemic deviants were presented together, only the large 
      pitch and phonemic contrasts elicited significant MMNs. When only pitch deviants 
      were presented, the medium and large pitch contrasts elicited significant MMNs. 
      The MMNs, in response to the medium and large pitch contrasts, were of similar 
      magnitude across the two contexts. CONCLUSIONS: Pitch and phonemic deviants can 
      be tested together provided the pitch contrast is relatively large. SIGNIFICANCE: 
      A combined neurophysiological test of phonemic and pitch discrimination, as 
      measured by the MMN, is a time-effective tool that may provide valuable 
      information about the underlying cause of poorly specified phonemic 
      representations in clinical populations.
FAU - Davids, Nina
AU  - Davids N
AD  - Behavioural Science Institute, Radboud University Nijmegen, The Netherlands. 
      n.davids@pwo.ru.nl
FAU - van den Brink, Danielle
AU  - van den Brink D
FAU - van Turennout, Miranda
AU  - van Turennout M
FAU - Mitterer, Holger
AU  - Mitterer H
FAU - Verhoeven, Ludo
AU  - Verhoeven L
LA  - eng
PT  - Journal Article
DEP - 20090501
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Acoustic Stimulation/*methods
MH  - Adolescent
MH  - Adult
MH  - Auditory Perception/*physiology
MH  - Brain/physiology
MH  - Electroencephalography
MH  - Female
MH  - Humans
MH  - Male
MH  - Models, Biological
MH  - *Phonetics
MH  - Pitch Discrimination/*physiology
MH  - Young Adult
EDAT- 2009/05/05 09:00
MHDA- 2009/06/13 09:00
CRDT- 2009/05/05 09:00
PHST- 2008/07/31 00:00 [received]
PHST- 2009/01/20 00:00 [revised]
PHST- 2009/01/20 00:00 [accepted]
PHST- 2009/05/05 09:00 [entrez]
PHST- 2009/05/05 09:00 [pubmed]
PHST- 2009/06/13 09:00 [medline]
AID - S1388-2457(09)00275-2 [pii]
AID - 10.1016/j.clinph.2009.01.018 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2009 Jun;120(6):1078-86. doi: 10.1016/j.clinph.2009.01.018. 
      Epub 2009 May 1.