PMID- 19412415
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1389-2029 (Print)
IS  - 1875-5488 (Electronic)
IS  - 1389-2029 (Linking)
VI  - 8
IP  - 7
DP  - 2007 Nov
TI  - Role of insulin and growth hormone/insulin-like growth factor-I signaling in 
      lifespan extension: rodent longevity models for studying aging and calorie 
      restriction.
PG  - 423-8
LID - 10.2174/138920207783591726 [doi]
AB  - Insulin/insulin-like growth factor-I (IGF-I) pathways are recognized as critical 
      signaling pathways involved in the control of lifespans in lower organisms to 
      mammals. Caloric restriction (CR) reduces plasma concentration of insulin, growth 
      hormone (GH), and IGF-I. CR retards various age-dependent disorders such as 
      nuerodegenerative diseases and extends lifespan in laboratory rodents. These 
      beneficial effects of CR are partly mimicked in spontaneous or genetically 
      engineered rodent models of reduced insulin and GH/IGF-I axis. Most of these 
      long-living rodents show increased insulin sensitivity; however, recent study has 
      revealed that some other rodents show normal or reduced insulin sensitivity. 
      Thus, increased insulin sensitivity might be not prerequisite for lifespan 
      extension in insulin/GH/IGF-I altered longevity rodent models. These results 
      highlighted that, for lifespan extension, the intracellular signaling molecules 
      of insulin/GH/IGF-I pathways might be more important than actual peripheral or 
      systemic insulin action.
FAU - Chiba, T
AU  - Chiba T
AD  - Department of Investigative Pathology, Nagasaki University Graduate School of 
      Biomedical Sciences, Nagasaki 852-8523, Japan.
FAU - Yamaza, H
AU  - Yamaza H
FAU - Shimokawa, I
AU  - Shimokawa I
LA  - eng
PT  - Journal Article
PL  - United Arab Emirates
TA  - Curr Genomics
JT  - Current genomics
JID - 100960527
PMC - PMC2647154
OTO - NOTNLM
OT  - GH
OT  - IGF-I
OT  - Insulin
OT  - calorie restriction.
EDAT- 2007/11/01 00:00
MHDA- 2007/11/01 00:01
PMCR- 2008/05/01
CRDT- 2009/05/05 09:00
PHST- 2007/10/01 00:00 [received]
PHST- 2007/10/15 00:00 [revised]
PHST- 2007/10/18 00:00 [accepted]
PHST- 2009/05/05 09:00 [entrez]
PHST- 2007/11/01 00:00 [pubmed]
PHST- 2007/11/01 00:01 [medline]
PHST- 2008/05/01 00:00 [pmc-release]
AID - CG-8-423 [pii]
AID - 10.2174/138920207783591726 [doi]
PST - ppublish
SO  - Curr Genomics. 2007 Nov;8(7):423-8. doi: 10.2174/138920207783591726.