PMID- 19412541
OWN - NLM
STAT- MEDLINE
DCOM- 20090817
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 4
IP  - 5
DP  - 2009
TI  - Cerebrospinal fluid concentration of brain-derived neurotrophic factor and 
      cognitive function in non-demented subjects.
PG  - e5424
LID - 10.1371/journal.pone.0005424 [doi]
LID - e5424
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) is an activity-dependent 
      secreted protein that is critical to organization of neuronal networks and 
      synaptic plasticity, especially in the hippocampus. We tested hypothesis that 
      reduced CSF BDNF is associated with age-related cognitive decline. 
      METHODOLOGY/PRINCIPAL FINDINGS, AND CONCLUSIONS/SIGNIFICANCE: CSF concentration 
      of BDNF, Abeta(42) and total tau were measured in 128 cognitively normal adults 
      (Normals), 21 patients with Alzheimer's disease (AD), and nine patients with Mild 
      Cognitive Impairment. Apolipoprotein E and BDNF SNP rs6265 genotype were 
      determined. Neuropsychological tests were performed at baseline for all subjects 
      and at follow-up visits in 50 Normals. CSF BDNF level was lower in AD patients 
      compared to age-matched Normals (p = 0.02). CSF BDNF concentration decreased with 
      age among Normals and was higher in women than men (both p<0.001). After 
      adjusting for age, gender, education, CSF Abeta(42) and total tau, and APOE and 
      BDNF genotypes, lower CSF BDNF concentration was associated poorer immediate and 
      delayed recall at baseline (both p<0.05) and in follow up of approximately 3 
      years duration (both p<0.01). CONCLUSIONS/SIGNIFICANCE: Reduced CSF BDNF was 
      associated with age-related cognitive decline, suggesting a potential mechanism 
      that may contribute in part to cognitive decline in older individuals.
FAU - Li, Ge
AU  - Li G
AD  - Department of Psychiatry and Behavioral Sciences, University of Washington School 
      of Medicine, Seattle, Washington, USA. gli@u.washington.edu
FAU - Peskind, Elaine R
AU  - Peskind ER
FAU - Millard, Steven P
AU  - Millard SP
FAU - Chi, Peter
AU  - Chi P
FAU - Sokal, Izabela
AU  - Sokal I
FAU - Yu, Chang-En
AU  - Yu CE
FAU - Bekris, Lynn M
AU  - Bekris LM
FAU - Raskind, Murray A
AU  - Raskind MA
FAU - Galasko, Douglas R
AU  - Galasko DR
FAU - Montine, Thomas J
AU  - Montine TJ
LA  - eng
GR  - R01 AG023185/AG/NIA NIH HHS/United States
GR  - U01 AG016976/AG/NIA NIH HHS/United States
GR  - AG023185/AG/NIA NIH HHS/United States
GR  - P50 AG005136/AG/NIA NIH HHS/United States
GR  - P50-AG005136/AG/NIA NIH HHS/United States
GR  - AG05136/AG/NIA NIH HHS/United States
GR  - P50 AG005136-26/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090501
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Apolipoproteins E)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Peptide Fragments)
RN  - 0 (amyloid beta-protein (1-42))
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/cerebrospinal fluid/genetics/psychology
MH  - Amyloid beta-Peptides/cerebrospinal fluid
MH  - Apolipoproteins E/genetics
MH  - Brain-Derived Neurotrophic Factor/*cerebrospinal fluid/genetics
MH  - Case-Control Studies
MH  - Cognition/*physiology
MH  - Cognition Disorders/cerebrospinal fluid/genetics/psychology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Memory/physiology
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Peptide Fragments/cerebrospinal fluid
MH  - Young Adult
PMC - PMC2671606
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2009/05/05 09:00
MHDA- 2009/08/18 09:00
PMCR- 2009/05/01
CRDT- 2009/05/05 09:00
PHST- 2009/01/25 00:00 [received]
PHST- 2009/04/01 00:00 [accepted]
PHST- 2009/05/05 09:00 [entrez]
PHST- 2009/05/05 09:00 [pubmed]
PHST- 2009/08/18 09:00 [medline]
PHST- 2009/05/01 00:00 [pmc-release]
AID - 09-PONE-RA-08373R1 [pii]
AID - 10.1371/journal.pone.0005424 [doi]
PST - ppublish
SO  - PLoS One. 2009;4(5):e5424. doi: 10.1371/journal.pone.0005424. Epub 2009 May 1.