PMID- 19412572
OWN - NLM
STAT- MEDLINE
DCOM- 20090818
LR  - 20211020
IS  - 1573-7284 (Electronic)
IS  - 0393-2990 (Print)
IS  - 0393-2990 (Linking)
VI  - 24
IP  - 6
DP  - 2009
TI  - Unfavourable risk factors for type 2 diabetes mellitus are already apparent more 
      than a decade before onset in a population-based study of older persons: from the 
      Age, Gene/Environment Susceptibility-Reykjavik Study (AGES-Reykjavik).
PG  - 307-14
LID - 10.1007/s10654-009-9343-x [doi]
AB  - We evaluated midlife risk factors of developing type 2 diabetes mellitus (T2DM) 
      in late life in a population-based study of older persons. A cohort of 2,251 
      persons, aged 65-96, participated in AGES-Reykjavik in 2002-2004; all attended 
      the Reykjavik Study 26 years earlier, at the mean age of 50. Based on 
      glucometabolic status in 2002-2004 the participants are divided into a 
      normoglycemic control group (n = 1,695), an impaired fasting glucose (IFG) group 
      (n = 313) and T2DM group (n = 243). Change in risk parameters from midlife is 
      evaluated retrospectively in these three groups. Since examined earlier 14.3% of 
      men and 8.2% of women developed T2DM. A family history of diabetes was reported 
      in 39.5% of T2DM compared to 19.3% in both IFG and normoglycemics. The T2DM and 
      IFG groups currently have higher levels of fasting triglycerides, greater body 
      mass index (BMI) and higher systolic blood pressure than normoglycemics and this 
      difference was already apparent in midlife. In late life, two or more metabolic 
      syndrome criteria are present in 60% of the T2DM groups compared to 25% in 
      normoglycemic groups. T2DM with impaired cardiovascular health is more marked in 
      women than men when compared with normoglycemics. Family history and higher 
      levels of BMI, triglycerides and systolic blood pressure in midlife are 
      associated with the development of T2DM in late life, suggesting risk can be 
      evaluated long before onset. A continued rise in risk factors throughout life 
      allows for more aggressive measures in preventing or delaying development of T2DM 
      and its effect on cardiovascular health.
FAU - Olafsdottir, Elin
AU  - Olafsdottir E
AD  - Icelandic Heart Association, Holtasmari 1, Kopavogur, Iceland. 
      elinolafs@hjarta.is
FAU - Aspelund, Thor
AU  - Aspelund T
FAU - Sigurdsson, Gunnar
AU  - Sigurdsson G
FAU - Thorsson, Bolli
AU  - Thorsson B
FAU - Benediktsson, Rafn
AU  - Benediktsson R
FAU - Harris, Tamara B
AU  - Harris TB
FAU - Launer, Lenore J
AU  - Launer LJ
FAU - Eiriksdottir, Gudny
AU  - Eiriksdottir G
FAU - Gudnason, Vilmundur
AU  - Gudnason V
LA  - eng
GR  - N01 AG012100/AG/NIA NIH HHS/United States
GR  - N01-AG-12100/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090502
PL  - Netherlands
TA  - Eur J Epidemiol
JT  - European journal of epidemiology
JID - 8508062
SB  - IM
MH  - Aged
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*epidemiology/genetics
MH  - Female
MH  - Glycemic Index
MH  - Health Status Indicators
MH  - Humans
MH  - Iceland/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Retrospective Studies
MH  - *Risk Factors
PMC - PMC3268120
MID - NIHMS195960
EDAT- 2009/05/05 09:00
MHDA- 2009/08/19 09:00
PMCR- 2012/01/29
CRDT- 2009/05/05 09:00
PHST- 2008/02/18 00:00 [received]
PHST- 2009/04/17 00:00 [accepted]
PHST- 2009/05/05 09:00 [entrez]
PHST- 2009/05/05 09:00 [pubmed]
PHST- 2009/08/19 09:00 [medline]
PHST- 2012/01/29 00:00 [pmc-release]
AID - 10.1007/s10654-009-9343-x [doi]
PST - ppublish
SO  - Eur J Epidemiol. 2009;24(6):307-14. doi: 10.1007/s10654-009-9343-x. Epub 2009 May 
      2.