PMID- 19414745
OWN - NLM
STAT- MEDLINE
DCOM- 20090526
LR  - 20230118
IS  - 1550-6606 (Electronic)
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 182
IP  - 10
DP  - 2009 May 15
TI  - Central memory CD8+ T cells induce graft-versus-host disease and mediate 
      graft-versus-leukemia.
PG  - 5938-48
LID - 10.4049/jimmunol.0802212 [doi]
AB  - In allogeneic hemopoietic stem cell transplantation, mature donor alphabeta T 
      cells in the allograft promote T cell reconstitution in the recipient and mediate 
      the graft-vs-leukemia (GVL) effect. Unfortunately, donor T cells can attack 
      nonmalignant host tissues and cause graft-vs-host disease (GVHD). It has 
      previously been shown that effector memory T cells not primed to alloantigen do 
      not cause GVHD yet transfer functional T cell memory and mediate GVL. Recently, 
      central memory T cells (T(CM)) have also been reported to not cause GVHD. In 
      contrast, in this study, we demonstrate that purified CD8(+) T(CM) not 
      specifically primed to alloantigens mediate GVHD in the MHC-mismatched C57BL/6 
      (B6)-->BALB/c and the MHC-matched, multiple minor histocompatibility 
      Ag-mismatched C3H.SW-->B6 strain pairings. CD8(+) T(CM) and naive T cells (T(N)) 
      caused similar histological disease in liver, skin, and bowel. B6 CD8(+) T(CM) 
      and T(N) similarly expanded in BALB/c recipients, and the majority of their 
      progeny produced IFN-gamma upon restimulation. However, in both models, CD8(+) 
      T(CM) induced milder clinical GVHD than did CD8(+) T(N). Nonetheless, CD8(+) 
      T(CM) and T(N) were similarly potent mediators of GVL against a mouse model of 
      chronic-phase chronic myelogenous leukemia. Thus, in contrast to what was 
      previously thought, CD8(+) T(CM) are capable of inducing GVHD and are 
      substantially different from T(EM) but only subtly so from T(N).
FAU - Zheng, Hong
AU  - Zheng H
AD  - Department of Medicine, Penn State Milton S. Hershey Medical Center, Hershey, PA 
      17033, USA.
FAU - Matte-Martone, Catherine
AU  - Matte-Martone C
FAU - Jain, Dhanpat
AU  - Jain D
FAU - McNiff, Jennifer
AU  - McNiff J
FAU - Shlomchik, Warren D
AU  - Shlomchik WD
LA  - eng
GR  - R01 CA096943/CA/NCI NIH HHS/United States
GR  - R01 HL066279/HL/NHLBI NIH HHS/United States
GR  - R01-CA96943/CA/NCI NIH HHS/United States
GR  - R01-HL 066279/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
SB  - IM
MH  - Animals
MH  - Bone Marrow Transplantation/*immunology
MH  - CD8-Positive T-Lymphocytes/*immunology
MH  - Disease Models, Animal
MH  - Flow Cytometry
MH  - Fluorescent Antibody Technique
MH  - Graft vs Host Disease/*immunology
MH  - Humans
MH  - Immunologic Memory
MH  - Leukemia, Experimental/*immunology/therapy
MH  - Mice
MH  - T-Lymphocyte Subsets/*immunology
PMC - PMC9844260
MID - NIHMS1621277
COIS- Disclosures The authors have no conflicting financial interests.
EDAT- 2009/05/06 09:00
MHDA- 2009/05/27 09:00
PMCR- 2023/01/17
CRDT- 2009/05/06 09:00
PHST- 2009/05/06 09:00 [entrez]
PHST- 2009/05/06 09:00 [pubmed]
PHST- 2009/05/27 09:00 [medline]
PHST- 2023/01/17 00:00 [pmc-release]
AID - 182/10/5938 [pii]
AID - 10.4049/jimmunol.0802212 [doi]
PST - ppublish
SO  - J Immunol. 2009 May 15;182(10):5938-48. doi: 10.4049/jimmunol.0802212.