PMID- 19416672
OWN - NLM
STAT- MEDLINE
DCOM- 20090526
LR  - 20220309
IS  - 1090-2430 (Electronic)
IS  - 0014-4886 (Print)
IS  - 0014-4886 (Linking)
VI  - 217
IP  - 1
DP  - 2009 May
TI  - Daily intermittent hypoxia augments spinal BDNF levels, ERK phosphorylation and 
      respiratory long-term facilitation.
PG  - 116-23
LID - 10.1016/j.expneurol.2009.01.017 [doi]
AB  - Acute intermittent hypoxia (AIH) elicits a form of respiratory plasticity known 
      as long-term facilitation (LTF). We hypothesized that: 1) daily AIH (dAIH) 
      preconditioning enhances phrenic and hypoglossal (XII) LTF in a rat strain with 
      low constitutive LTF expression; 2) dAIH induces brain-derived neurotrophic 
      factor (BDNF), a critical protein for phrenic LTF (pLTF) in the cervical spinal 
      cord; and 3) dAIH increases post-AIH extracellular regulated kinase (ERK) 
      activation. Phrenic and XII motor output were monitored in anesthetized dAIH- or 
      sham-treated Brown Norway rats with and without acute AIH. pLTF was observed in 
      both sham (18+/-9% baseline; 60 min post-hypoxia; p<0.05; n=18) and dAIH treated 
      rats (37+/-8%; p<0.05; n=14), but these values were not significantly different 
      (p=0.13). XII LTF was not observed in sham-treated rats (4+/-5%), but was 
      revealed in dAIH pretreated rats (48+/-18%; p<0.05). dAIH preconditioning 
      increased basal ventral cervical BDNF protein levels (24+/-8%; p<0.05), but had 
      no significant effect on ERK phosphorylation. AIH increased BDNF in sham 
      (25+/-8%; p<0.05), but not dAIH-pretreated rats (-7+/-4%), and had complex 
      effects on ERK phosphorylation (ERK2 increased in shams whereas ERK1 increased in 
      dAIH-treated rats). Thus, dAIH elicits metaplasticity in LTF, revealing XII LTF 
      in a rat strain with no constitutive XII LTF expression. Increased BDNF synthesis 
      may no longer be necessary for phrenic LTF following dAIH preconditioning since 
      BDNF concentration is already elevated.
FAU - Wilkerson, Julia E R
AU  - Wilkerson JE
AD  - Department of Comparative Biosciences, University of Wisconsin, School of 
      Veterinary Medicine, Madison, WI 53706, USA.
FAU - Mitchell, Gordon S
AU  - Mitchell GS
LA  - eng
GR  - T32 HL007654-18/HL/NHLBI NIH HHS/United States
GR  - R01 HL080209/HL/NHLBI NIH HHS/United States
GR  - T32 HL007654-20/HL/NHLBI NIH HHS/United States
GR  - T32 HL007654/HL/NHLBI NIH HHS/United States
GR  - T32 HL007654-16/HL/NHLBI NIH HHS/United States
GR  - HL80209/HL/NHLBI NIH HHS/United States
GR  - R01 HL080209-01/HL/NHLBI NIH HHS/United States
GR  - HL 07654/HL/NHLBI NIH HHS/United States
GR  - T32 HL007654-19/HL/NHLBI NIH HHS/United States
GR  - R01 HL080209-03/HL/NHLBI NIH HHS/United States
GR  - R01 HL080209-02/HL/NHLBI NIH HHS/United States
GR  - T32 HL007654-17/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20090203
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
SB  - IM
MH  - Animals
MH  - Blood Gas Analysis/methods
MH  - Blood Pressure
MH  - Body Mass Index
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Extracellular Signal-Regulated MAP Kinases/*metabolism
MH  - Hypoglossal Nerve/physiopathology
MH  - *Hypoxia/metabolism/pathology/physiopathology
MH  - Long-Term Potentiation/*physiology
MH  - Male
MH  - Phosphorylation/physiology
MH  - Phrenic Nerve/physiopathology
MH  - Radioimmunoassay/methods
MH  - Rats
MH  - *Respiration
MH  - Spinal Cord/*metabolism
MH  - Time Factors
MH  - Vagotomy/methods
PMC - PMC2691872
MID - NIHMS115682
EDAT- 2009/05/07 09:00
MHDA- 2009/05/27 09:00
PMCR- 2010/05/01
CRDT- 2009/05/07 09:00
PHST- 2008/07/04 00:00 [received]
PHST- 2009/01/23 00:00 [revised]
PHST- 2009/01/27 00:00 [accepted]
PHST- 2009/05/07 09:00 [entrez]
PHST- 2009/05/07 09:00 [pubmed]
PHST- 2009/05/27 09:00 [medline]
PHST- 2010/05/01 00:00 [pmc-release]
AID - S0014-4886(09)00039-9 [pii]
AID - 10.1016/j.expneurol.2009.01.017 [doi]
PST - ppublish
SO  - Exp Neurol. 2009 May;217(1):116-23. doi: 10.1016/j.expneurol.2009.01.017. Epub 
      2009 Feb 3.