PMID- 19417173
OWN - NLM
STAT- MEDLINE
DCOM- 20091102
LR  - 20111117
IS  - 1469-0756 (Electronic)
IS  - 0032-5473 (Linking)
VI  - 85
IP  - 1002
DP  - 2009 Apr
TI  - Insulin U-500 in severe insulin resistance in type 2 diabetes mellitus.
PG  - 219-22
LID - 10.1136/pgmj.2008.073379 [doi]
AB  - Some patients with type 2 diabetes mellitus (T2DM) are profoundly insulin 
      resistant and require large insulin doses to achieve optimal glycaemic control. 
      However, large volumes of subcutaneous conventional U-100 insulin can cause 
      discomfort at the injection site, resulting in poor concordance with insulin 
      therapy. One therapeutic option is the use of U-500 insulin, thus reducing the 
      insulin volume by 80%. This review will address the practical issues associated 
      with the use of U-500, clinical efficacy and safety aspects of this concentrated 
      insulin, which has an important role in a subgroup of patients with T2DM.
FAU - Crasto, W
AU  - Crasto W
AD  - Department of Diabetes and Endocrinology, University Hospitals of Leicester NHS 
      Trust, UK.
FAU - Jarvis, J
AU  - Jarvis J
FAU - Hackett, E
AU  - Hackett E
FAU - Nayyar, V
AU  - Nayyar V
FAU - McNally, P G
AU  - McNally PG
FAU - Davies, M J
AU  - Davies MJ
FAU - Lawrence, I G
AU  - Lawrence IG
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Postgrad Med J
JT  - Postgraduate medical journal
JID - 0234135
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
SB  - IM
MH  - Diabetes Mellitus, Type 2/complications/*drug therapy/economics
MH  - Drug Costs
MH  - Humans
MH  - Hypoglycemic Agents/*administration & dosage/adverse effects/economics
MH  - Insulin/*administration & dosage/adverse effects/economics
MH  - Insulin Resistance/*physiology
MH  - Obesity/complications
MH  - Patient Satisfaction
MH  - Treatment Outcome
MH  - Weight Gain
RF  - 25
EDAT- 2009/05/07 09:00
MHDA- 2009/11/03 06:00
CRDT- 2009/05/07 09:00
PHST- 2009/05/07 09:00 [entrez]
PHST- 2009/05/07 09:00 [pubmed]
PHST- 2009/11/03 06:00 [medline]
AID - 85/1002/219 [pii]
AID - 10.1136/pgmj.2008.073379 [doi]
PST - ppublish
SO  - Postgrad Med J. 2009 Apr;85(1002):219-22. doi: 10.1136/pgmj.2008.073379.