PMID- 19417654
OWN - NLM
STAT- MEDLINE
DCOM- 20090924
LR  - 20090715
IS  - 1531-7013 (Electronic)
IS  - 1087-2418 (Linking)
VI  - 14
IP  - 4
DP  - 2009 Aug
TI  - HLAMatchmaker-based definition of structural human leukocyte antigen epitopes 
      detected by alloantibodies.
PG  - 403-9
LID - 10.1097/MOT.0b013e32832ca2b8 [doi]
AB  - PURPOSE OF REVIEW: This review addresses the concept that human leukocyte antigen 
      (HLA) antibody specificity should be determined to HLA epitopes rather than HLA 
      antigens. RECENT FINDINGS: HLAMatchmaker is a computer algorithm that considers 
      small configurations of polymorphic residues referred to as eplets as essential 
      components of HLA epitopes. This overview describes recent developments that have 
      increased our understanding of structural epitope antigenicity, that is, 
      reactivity with specific antibody and immunogenicity, that is, its ability to 
      induce an antibody response. SUMMARY: A determination of the repertoire of 
      immunogenic epitopes is important for HLA compatibility testing and the 
      identification of acceptable mismatches for sensitized patients.
FAU - Duquesnoy, Rene J
AU  - Duquesnoy RJ
AD  - Division of Transplantation Pathology, University of Pittsburgh Medical Center, 
      Pittsburgh, PA 15261, USA. Duquesnoyr@upmc.edu
FAU - Marrari, Marilyn
AU  - Marrari M
LA  - eng
GR  - R01-AI-55933/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Curr Opin Organ Transplant
JT  - Current opinion in organ transplantation
JID - 9717388
RN  - 0 (Epitopes)
RN  - 0 (HLA Antigens)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - Algorithms
MH  - Antibody Specificity
MH  - Computer Simulation
MH  - *Epitope Mapping
MH  - *Epitopes
MH  - Graft Rejection/immunology/prevention & control
MH  - HLA Antigens/chemistry/*immunology
MH  - *Histocompatibility
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - Isoantibodies/*blood
MH  - Models, Molecular
MH  - *Organ Transplantation/adverse effects
MH  - Protein Conformation
MH  - *Tissue Donors
RF  - 35
EDAT- 2009/05/07 09:00
MHDA- 2009/09/25 06:00
CRDT- 2009/05/07 09:00
PHST- 2009/05/07 09:00 [entrez]
PHST- 2009/05/07 09:00 [pubmed]
PHST- 2009/09/25 06:00 [medline]
AID - 10.1097/MOT.0b013e32832ca2b8 [doi]
PST - ppublish
SO  - Curr Opin Organ Transplant. 2009 Aug;14(4):403-9. doi: 
      10.1097/MOT.0b013e32832ca2b8.