PMID- 19417663
OWN - NLM
STAT- MEDLINE
DCOM- 20090803
LR  - 20090520
IS  - 1531-6998 (Electronic)
IS  - 1068-9508 (Linking)
VI  - 17
IP  - 3
DP  - 2009 Jun
TI  - Localized immunoglobulin E expression in allergic rhinitis and nasal polyposis.
PG  - 216-22
LID - 10.1097/MOO.0b013e32832ad23d [doi]
AB  - PURPOSE OF REVIEW: This article reviews recent literature on local tissue 
      identification of immunoglobulin E (IgE) in various sinonasal inflammatory 
      conditions. Discussions of local IgE expression in allergic and nonallergic 
      rhinitis, atopic and nonatopic sinonasal polyposis, and allergic fungal 
      rhinosinusitis are included. RECENT FINDINGS: Increased levels of IgE and 
      positive reactivity on nasal allergen provocation tests have been demonstrated in 
      nasal lavage fluid of patients with negative systemic allergy testing. In 
      addition, elevated levels of Alternaria alternata-specific IgE have been 
      identified in nasal polyp patients; this is hypothesized as a contributory factor 
      in the development of nasal polyposis. Further evidence supports the role of 
      local IgE to Staphylococcus aureus superantigens in atopic and nonatopic nasal 
      polyposis. Finally, local IgE specific for a range of antigens has been 
      identified in sinus and inferior turbinate tissue in patients with allergic 
      fungal rhinosinusitis. SUMMARY: Increased levels of IgE have been identified in 
      sinonasal tissues in allergic and nonallergic rhinitis, atopic and nonatopic 
      sinonasal polyposis, and allergic fungal rhinosinusitis. The ability to identify 
      local tissue IgE in inflammatory sinonasal disease states may have significant 
      diagnostic and therapeutic implications.
FAU - Wise, Sarah K
AU  - Wise SK
AD  - Department of Otolaryngology - Head and Neck Surgery, Emory University, Atlanta, 
      Georgia, USA.
FAU - Ahn, Chadwick N
AU  - Ahn CN
FAU - Schlosser, Rodney J
AU  - Schlosser RJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Curr Opin Otolaryngol Head Neck Surg
JT  - Current opinion in otolaryngology & head and neck surgery
JID - 9417024
RN  - 0 (Superantigens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Alternaria/immunology
MH  - Antibody Specificity
MH  - Humans
MH  - Immunoglobulin E/*metabolism
MH  - Nasal Mucosa/immunology/pathology
MH  - Nasal Polyps/*immunology/pathology
MH  - Nasal Provocation Tests
MH  - Paranasal Sinuses/immunology/pathology
MH  - Rhinitis, Allergic, Perennial/*immunology/pathology
MH  - Rhinitis, Allergic, Seasonal/*immunology/pathology
MH  - Staphylococcus aureus/immunology
MH  - Superantigens/immunology
MH  - Turbinates/immunology
RF  - 41
EDAT- 2009/05/07 09:00
MHDA- 2009/08/04 09:00
CRDT- 2009/05/07 09:00
PHST- 2009/05/07 09:00 [entrez]
PHST- 2009/05/07 09:00 [pubmed]
PHST- 2009/08/04 09:00 [medline]
AID - 10.1097/MOO.0b013e32832ad23d [doi]
PST - ppublish
SO  - Curr Opin Otolaryngol Head Neck Surg. 2009 Jun;17(3):216-22. doi: 
      10.1097/MOO.0b013e32832ad23d.