PMID- 19419072
OWN - NLM
STAT- MEDLINE
DCOM- 20091019
LR  - 20191111
IS  - 0034-7744 (Print)
IS  - 0034-7744 (Linking)
VI  - 56
IP  - 4
DP  - 2008 Dec
TI  - Adverse reactions from community directed treatment with ivermectin (CDTI) for 
      onchocerciasis and loiasis in Ondo State, Nigeria.
PG  - 1635-43
AB  - Onchocerciasis is an endemic disease in Ondo state, Nigeria. Community directed 
      distribution of ivermectin is currently on-going in some local government areas 
      of the state. Randomly selected persons (2331 males and 2469 females) were 
      interviewed using a modified rapid assessment procedure for Loa loa (RAPLOA) to 
      assess community directed treatment with ivermectin. The retrospective study 
      evaluated the coverage, impacts and adverse reactions to the drug treatment. A 
      questionnaire was administered by house-to-house visit in six local government 
      areas, implementing community directed treatment with ivermectin (CDTI) in this 
      bioclimatic zone. A total of 2,398 respondents were reported to have participated 
      in the treatment. The overall ivermectin coverage of 49.96% was recorded (range 
      0-52% in different communities). Adverse reactions from ivermectin administration 
      were experienced in 38% of individuals. Diverse adverse reactions experienced 
      included predominantly itching (18.50%); oedema, especially of the face and the 
      limbs (8.2%); rashes (3.4%) and body weakness (2.4%). Expulsion of intestinal 
      worms occurred in 0.96% of the respondents. The occurrence of adverse reactions 
      in relation to age categories was statistically significant. Neither fatal nor 
      severe adverse reactions were reported by respondents. Significantly, despite 
      experienced adverse reactions, continued participation, acceptability and 
      compliance to ivermectin treatment was expressed by the various communities. This 
      attitude is in consonance with the African Programme for Onchocerciasis Control 
      (APOC) objectives. Rev. Biol.
FAU - Otubanjo, O A
AU  - Otubanjo OA
AD  - Department of Zoology, University of Lagos, Akoka, Yaba, Lagos, Nigeria. 
      adetoro2001@yahoo.com
FAU - Adeoye, G O
AU  - Adeoye GO
FAU - Ibidapo, C A
AU  - Ibidapo CA
FAU - Akinsanya, B
AU  - Akinsanya B
FAU - Okeke, P
AU  - Okeke P
FAU - Atalabi, T
AU  - Atalabi T
FAU - Adejai, E T
AU  - Adejai ET
FAU - Braide, E
AU  - Braide E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Costa Rica
TA  - Rev Biol Trop
JT  - Revista de biologia tropical
JID - 0404267
RN  - 0 (Antiparasitic Agents)
RN  - 70288-86-7 (Ivermectin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Antiparasitic Agents/*adverse effects/therapeutic use
MH  - Endemic Diseases/*prevention & control
MH  - Female
MH  - Humans
MH  - Ivermectin/*adverse effects/therapeutic use
MH  - Loiasis/*drug therapy/epidemiology/prevention & control
MH  - Male
MH  - Middle Aged
MH  - National Health Programs
MH  - Nigeria/epidemiology
MH  - Onchocerciasis/*drug therapy/epidemiology/prevention & control
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2009/05/08 09:00
MHDA- 2009/10/20 06:00
CRDT- 2009/05/08 09:00
PHST- 2009/05/08 09:00 [entrez]
PHST- 2009/05/08 09:00 [pubmed]
PHST- 2009/10/20 06:00 [medline]
AID - 10.15517/rbt.v56i4.5750 [doi]
PST - ppublish
SO  - Rev Biol Trop. 2008 Dec;56(4):1635-43. doi: 10.15517/rbt.v56i4.5750.