PMID- 19420294
OWN - NLM
STAT- MEDLINE
DCOM- 20090825
LR  - 20220722
IS  - 1522-1490 (Electronic)
IS  - 0363-6119 (Print)
IS  - 0363-6119 (Linking)
VI  - 297
IP  - 1
DP  - 2009 Jul
TI  - Effect of acute and chronic caloric restriction and metabolic glucoprivation on 
      spontaneous physical activity in obesity-prone and obesity-resistant rats.
PG  - R176-84
LID - 10.1152/ajpregu.90866.2008 [doi]
AB  - Caloric restriction (CR) and metabolic glucoprivation affect spontaneous physical 
      activity (SPA), but it's unknown whether these treatments similarly affect SPA in 
      selectively bred obesity-prone (OP) and -resistant (OR) rats. OR rats have 
      greater basal SPA and are more responsive to treatments that modulate SPA, such 
      as orexin A administration. We hypothesized that OR rats would be more sensitive 
      to other treatments modulating SPA. To test this, continuous 24-h SPA was 
      measured before and during acute (24 h) and chronic (8 wk) CR in OR, OP, and 
      Sprague-Dawley rats. Pharmacological glucoprivation was produced by injection of 
      2-deoxyglucose (2-DG), and SPA was measured 5 h postinjection. Acute CR increased 
      SPA in all groups; however, the effect was dependent on the index of SPA and time 
      interval during the 24-h time period. In contrast to OR rats, chronic CR 
      increased distance traveled, ambulatory episodes, and time spent in ambulation 
      and stereotypy during the time interval preceding anticipation of food in OP and 
      Sprague-Dawley rats. Although the effects of 2-DG treatment on SPA were minimal, 
      OR rats had significantly greater SPA than OP and Sprague-Dawley rats independent 
      of treatment. That chronic CR failed to result in significant changes in SPA in 
      OR rats suggests that these rats may be especially unresponsive to treatments 
      modulating feeding. This insensitivity coupled with elevated basal SPA levels may 
      in part mediate phenotypic traits of lean rats.
FAU - Teske, J A
AU  - Teske JA
AD  - University of Minnesota, Department of Food Science and Nutrition, St. Paul, 
      Minnesota, USA. teskeja@umn.edu
FAU - Kotz, C M
AU  - Kotz CM
LA  - eng
GR  - I01 RX000441/RX/RRD VA/United States
GR  - R01 DK078985/DK/NIDDK NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20090506
PL  - United States
TA  - Am J Physiol Regul Integr Comp Physiol
JT  - American journal of physiology. Regulatory, integrative and comparative 
      physiology
JID - 100901230
RN  - 0 (Dietary Fats)
RN  - 9G2MP84A8W (Deoxyglucose)
SB  - IM
MH  - Animals
MH  - Body Weight
MH  - *Caloric Restriction
MH  - Deoxyglucose/administration & dosage/*metabolism
MH  - Dietary Fats
MH  - Disease Models, Animal
MH  - Eating
MH  - *Energy Metabolism
MH  - Injections, Subcutaneous
MH  - *Locomotion
MH  - Male
MH  - Obesity/etiology/*metabolism/physiopathology
MH  - Phenotype
MH  - Rats
MH  - Rats, Wistar
MH  - Time Factors
PMC - PMC9281555
EDAT- 2009/05/08 09:00
MHDA- 2009/08/26 09:00
PMCR- 2010/07/01
CRDT- 2009/05/08 09:00
PHST- 2009/05/08 09:00 [entrez]
PHST- 2009/05/08 09:00 [pubmed]
PHST- 2009/08/26 09:00 [medline]
PHST- 2010/07/01 00:00 [pmc-release]
AID - 90866.2008 [pii]
AID - 10.1152/ajpregu.90866.2008 [doi]
PST - ppublish
SO  - Am J Physiol Regul Integr Comp Physiol. 2009 Jul;297(1):R176-84. doi: 
      10.1152/ajpregu.90866.2008. Epub 2009 May 6.