PMID- 19422328
OWN - NLM
STAT- MEDLINE
DCOM- 20090729
LR  - 20230124
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 9
IP  - 5
DP  - 2009 May
TI  - Signal transduction pathways involved in brain death-induced renal injury.
PG  - 989-97
LID - 10.1111/j.1600-6143.2009.02587.x [doi]
AB  - Kidneys derived from brain death organ donors show an inferior survival when 
      compared to kidneys derived from living donors. Brain death is known to induce 
      organ injury by evoking an inflammatory response in the donor. Neuronal injury 
      triggers an inflammatory response in the brain, leading to endothelial 
      dysfunction and the release of cytokines in the circulation. Serum levels of 
      interleukin-6, -8, -10, and monocyte chemoattractant protein-1 (MCP-1) are 
      increased after brain death. Binding with cytokine-receptors in kidneys 
      stimulates activation of nuclear factor-kappa B (NF-kappaB), selectins, adhesion 
      molecules and production of chemokines leading to cellular influx. 
      Mitogen-activated protein kinases (MAP-kinases) mediate inflammatory responses 
      and together with NF-kappaB they seem to play an important role in brain death 
      induced renal injury. Altering the activation state of MAP-kinases could be a 
      promising drug target for early intervention to reduce cerebral injury related 
      donor kidney damage and improve outcome after transplantation.
FAU - Bouma, H R
AU  - Bouma HR
AD  - Department of Clinical Pharmacology, Groningen University Institute of Drug 
      Exploration, University Medical Center Groningen, The Netherlands.
FAU - Ploeg, R J
AU  - Ploeg RJ
FAU - Schuurs, T A
AU  - Schuurs TA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of 
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
RN  - 0 (Chemokines)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
SB  - IM
MH  - Blood-Brain Barrier/physiology
MH  - *Brain Death
MH  - Chemokines/biosynthesis/genetics
MH  - Endothelium, Vascular/pathology
MH  - Extracellular Signal-Regulated MAP Kinases/metabolism
MH  - Humans
MH  - Inflammation/genetics/pathology/physiopathology
MH  - Kidney/*injuries/*pathology
MH  - Kidney Transplantation/mortality/*statistics & numerical data
MH  - Neurons/pathology
MH  - *Signal Transduction
MH  - *Tissue Donors
MH  - Transcription, Genetic
RF  - 135
EDAT- 2009/05/09 09:00
MHDA- 2009/07/30 09:00
CRDT- 2009/05/09 09:00
PHST- 2009/05/09 09:00 [entrez]
PHST- 2009/05/09 09:00 [pubmed]
PHST- 2009/07/30 09:00 [medline]
AID - S1600-6135(22)01661-6 [pii]
AID - 10.1111/j.1600-6143.2009.02587.x [doi]
PST - ppublish
SO  - Am J Transplant. 2009 May;9(5):989-97. doi: 10.1111/j.1600-6143.2009.02587.x.